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SRP6006

Sigma-Aldrich

IL-1RA murine

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

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Synonym(s):
ICIL-1RA, IL-1ra3, IL1 inhibitor, IL1F3, IRAP
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

form

lyophilized

mol wt

17.4 kDa

packaging

pkg of 50 μg

impurities

Endotoxin, tested

NCBI accession no.

P25085

UniProt accession no.

P25085

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... IL-1RA(16181)

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SRP6006

IL-1RA murine

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IL-1Ra human

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SRP3083

IL-1 beta human

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SRP3310

IL-1ALPHA human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

mol wt

17.4 kDa

mol wt

17.2 kDa

mol wt

17.3 kDa

mol wt

18.0 kDa

packaging

pkg of 50 μg

packaging

pkg of 100 μg

packaging

pkg of 10 μg

packaging

pkg of 10 μg

General description

Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1 ra Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques.
Interleukin-1 receptor antagonist (IL-1 RA) is a member of the interleukin 1 cytokine family. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL-1RA mouse recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques.

Application

IL-1RA murine has been used as an antagonist to the interleukin-1 receptor in fibroblasts.

Biochem/physiol Actions

Interleukin-1 receptor antagonist (IL-1Ra) protein mediates the inhibition of interleukin 1-α (IL1A) and interleukin 1-β (IL1B) activities. It is also involved in the modulation of IL-1 related immune and inflammatory responses. A polymorphism in the IL-1Ra gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1Ra is effective in treating bronchopulmonary dysplasia in murine models.

Physical form

Lyophilized from H?O containing NaHCO?

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile ddH?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Athanasios Didangelos et al.
Scientific reports, 6, 21607-21607 (2016-02-24)
Spinal cord injury is characterized by acute cellular and axonal damage followed by aggressive inflammation and pathological tissue remodelling. The biological mediators underlying these processes are still largely unknown. Here we apply an innovative proteomics approach targeting the enriched extracellular
W P Arend et al.
Annual review of immunology, 16, 27-55 (1998-05-23)
The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two structural variants of IL-1Ra have previously been described: a 17-kDa form that is secreted from
Christine B Bui et al.
Frontiers in immunology, 10, 1480-1480 (2019-07-30)
Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions. The abundance of interleukin-1 (IL-1) is strongly correlated with the severity and long-term
The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer.
E M El-Omar et al.
Nature, 412(6842), 99-99 (2002-01-26)
B L Langdahl et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(3), 402-414 (2000-04-06)
Interleukin-1beta (IL-1beta) is a potent stimulator of bone resorption, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1 receptor antagonist (IL-1ra) is a competitive inhibitor of IL-1beta effects and the biological effects of IL-1beta are
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