SRP8026
Annexin V human
recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)
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Synonym(s):
Annexin A5, Calphobindin I, EC 2.7.1.23, Endonexin II, Placental anticoagulantprotein I
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
tag
GST tagged
Assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~52 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
activity assay: suitable
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ANXA5(308)
General description
Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.
Application
Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).
Biochem/physiol Actions
Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.
Physical form
Lyophilized from PBS, pH 7.4.
Reconstitution
Reconstitute with 100 μL deionized water.
Other Notes
Recombinant human annexin V fused to a GST-tag.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Claire Pluchart et al.
Journal of thrombosis and thrombolysis, 48(2), 195-202 (2019-06-09)
Thromboembolic events are frequent and serious complications of acute lymphoblastic leukaemia treatment. The importance of chemotherapy in the pathogenesis of this increased risk is enhanced by the fact that thrombosis rarely occurs at diagnosis. Our study aims at investigating the
Shruti Sanjay Taparia et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 130-140 (2016-10-25)
Over the last four centuries, cocoa and chocolate have been described as having potential medicinal value. As of today, Theobroma cacao L. (Sterculiaceae) and its products are consumed worldwide. They are of great research interest because of the concentration dependent
Jesse D Gelles et al.
Cell death & disease, 7(12), e2493-e2493 (2016-12-03)
Quantitative and kinetic analyses of apoptotic cell death are integral components of exploring cell biology, measuring cellular stress responses, and performing high-throughput genomic/RNAi/drug screens. Here, we present a detailed method that integrates robust kinetic real-time high-content imaging with Annexin V
Xuerui Zhang et al.
Oncotarget, 8(26), 42602-42612 (2017-04-14)
Annexin V, a protein with high affinity to phosphatidylserine (PS) in a calcium dependent manner, has been widely used to probe apoptosis. Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of
Shanyue Wang et al.
International immunopharmacology, 84, 106513-106513 (2020-04-25)
Ischemia-reperfusion (I/R) injury causes cardiac dysfunction through several mechanisms including oxidative stress and pro-inflammation. Eleutheroside E (EE) has protective effects in ischemia tissue and anti-inflammatory action. However, the effect of EE on I/R-injured cardiomyocytes is unknown. In this study, we
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