T3067

Monoclonal Anti-TRAIL antibody produced in mouse

clone 75411, purified immunoglobulin, lyophilized powder

• Synonym(s): Anti-Apo-2L, Anti-TNF-Related Apoptosis-Inducing Ligand, Anti-TNFSF10
• MDL number: MFCD01868284
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 75411, monoclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8-25 μg/mL using human brain (occipital cortex) tissue sections; neutralization: 28 ng/mL using L929 mouse fibroblast cell line
• isotype: IgG1
• UniProt accession no.: P50591
• storage temp.: −20°C
• Gene Information: human ... TNFSF10(8743)

Description

General description

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) cytokine family. This ligand is a type II transmembrane protein that contains a short cytoplasmic N-terminal domain and a long C-terminal extracellular receptor-binding domain. TRAIL is highly expressed in immune system cells. The TRAIL gene is located on the human chromosome at 3q26.31.

Immunogen

purified, NSO-derived, recombinant human TRAIL extracellular domain.

Application

Monoclonal Anti-TRAIL antibody produced in mouse has been used in fluorescence-activated cell sorting (FACS).

Biochem/physiol Actions

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to TRAIL 1 & 2 receptors and induces apoptosis. This ligand is involved in the homeostasis of T-cells and natural killer (NK) cells. TRAIL also aids in the T-cell-mediated killing of virus-infected cells and oncogenic transformed cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable