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AlPhos and [(AlPhosPd)2•COD] for Pd-Catalyzed Fluorination
Fluorine containing aromatics (ArF) are desirable compounds with applications in medicinal chemistry and the agricultural industry.
AISF: A Stable, Solid Alternative to Sulfuryl Fluoride Gas
A solid and bench-stable alternative to sulfuryl fluoride gas has been developed, 4-(Acetylamino)phenyl]imidodisulfuryl difluoride (ASIF). ASIF is a shelf-stable, crystallilne reagent for the installation of the valuable SO2F functional group.
Trimethyl(trifluoromethyl)silane (Ruppert–Prakash Reagent)
Technical article for Trimethyl(trifluoromethyl)silane (Ruppert–Prakash Reagent)
Fluoroalkylation: Expansion of Togni Reagents
The fluoroalkylation toolbox now includes Togni reagents, hypervalent iodine perfluoroalkylation reagents, fluoroalkyl bromides, silanes, carboxylates, and sulfonyl fluorides for late stage fluoroalkylation.
XtalFluor-E® and XtalFluor-M®: Convenient, Crystalline Deoxofluorination Reagents
This is an article regarding XtalFluor-E® and XtalFluor-M®: Convenient, Crystalline Deoxofluorination Reagents.
TADDOL
The chiral auxiliaries TADDOLs (α,α,α,α-tetraaryl-1,3-dioxolane-4,5- dimethanols) developed by Seebach's group have found numerous applications in asymmetric synthesis ranging from utilization as stoichiometric chiral reagents or in Lewis acid mediated reactions, to roles in catalytic hydrogenation and stereoregular metathesis polymerization.
Diethylaminosulfur Trifluoride (DAST)
Diethylaminosulfur trifluoride (DAST)
Acid Halogenation Reagents
The generation of an acid chloride is an obvious way to activate the carboxy group for amide bond formation. However, practical application of acid chlorides in peptide synthesis is restricted, because they are prone to side reactions and racemization.
Deoxyfluorination with 2-Pyridinesulfonyl Fluoride (PyFluor)
The prevalence of organofluorine compounds in industry and drug design necessitates the ability to introduce C–F bonds to molecules.
Trifluoromethylator™, A Robust Arene Trifluoromethylation Reagent: (Phen)Cu-CF3*
(Phen)Cu-CF3 (cat. #L510009) is an easily handled, thermally stable, single-component reagent for the trifluoromethylation of aryl iodides.
Fluorinating Reagents
The importance of selectively fluorinating compounds in medicinal chemistry, biology, and organic synthesis is well appreciated and provides a major impetus to the discovery of new and mild fluorinating agents that can operate safely and efficiently.
Sulfonyl Chlorides and Sulfonamides
Sulfonyl chlorides are often chosen as building blocks in medicinal chemistry for their ability to easily react with heterocyclic amines to create complex sulfonamides.
Selectfluor™
Selectfluor™
PhenoFluor™ Solution for Convenient, One-step Deoxyfluorination
The functional-group-tolerant, one-step conversion of phenols to aryl fluorides is a highly desirable process. PhenoFluor™ solution, provides straightforward method to fluorinate alcohol and phenols without preactivation and regioselectively fluorinate highly functionalized late-stage intermediates.
HPLC Separation of Fluorinated Pharmaceutical Compounds on Supelco Ascentis Columns
Fluorinated compounds possess distinct characteristics that confer desirable physico-chemical properties compared to their non-fl uorinated analogs. Their abundance in pharmaceuticals, chemicals, consumer products and as environmental pollutants dictates the need for a reliable analytical method. Ascentis HPLC columns, by virtue...