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p53: DNA Damage Response and Cancer
p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.
Hypoxia Detection Assays
Hypoxia detection assays to measure oxygen levels in both live and fixed cells and tissues.
Phosphoprotein Phosphatases (Serine/Threonine)
We offers many products related to phosphoprotein phosphatases (Serine/Threonine) for your research needs.
Dopamine and Norepinephrine Metabolism
Either monoamine oxidase A (MAO) or catechol-O-methyltransferase (COMT) can catalyze the first step in catecholamine catabolism. The potentially toxic aldehyde intermediate generated in the MAO reaction (3,4-dihydroxyphenylacetaldehyde for dopamine, 3,4-dihydroxyphenylglycolaldehyde for norepinephrine) is either rapidly reduced to an alcohol (by
GABA Transporters
Sigma-Aldrich offers many products related to GABA transporters for your research needs.
Opioid Receptors
We offers many products related to opioid receptors for your research needs.
Inhibition of Protein Synthesis by Antibiotics
Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial
Glutamate/GABA Synthesis and Metabolism
Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. The neurotransmitter glutamate can be synthesized from glutamine by the action of
Abl
Sigma-Aldrich offers many products related to Abl for your research needs.
Protein Expression Systems
The development of genetic engineering and cloning has opened many possibilities of expression and isolation of heterologous proteins for research purposes. Considerable advances in technology have enabled expression and isolation of recombinant proteins in large scale.
Sensor Dyes
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
PDGFR
Sigma-Aldrich offers many products related to PDGFR for your research needs.
Chemokine Receptors
We offer many products related to chemokine receptors for your research needs.
Target Identification & Validation for Early Drug Discovery
Target identification, validation and characterization for early stages of drug discovery. Identifying drug target via genetic association, expression profiling.
FAK
The focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that distinctly co-localizes with integrins at sites of attachment to their ligands.
Antilipemic Agents
Randomized controlled clinical studies have suggested 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in both primary and secondary prevention of cardiovascular disease (CVD) events.
Signal Peptide Optimization: Effect On Recombinant Monoclonal IgG Productivity, Product Quality And Antigen-Binding Affinity
A signal peptide is a 5-30 amino acid (aa) peptide present at the N-terminus of secretory proteins.
Cannabinoid Receptors
We offer many products related to cannabinoid receptors for your research needs.
Glycogen Synthase Kinase 3 (GSK-3) Overview
We offers many products related to GSK-3 for your research needs.
Phase I Drug Metabolism
Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs
Histamine Receptors
We offers many products related to histamine receptors for your research needs.
Poster Gallery
Cell Signaling and Neuroscience scientific posters covering topics in antibody microarrays, immunoprecipitation, nuclear extraction and ANTI-FLAG M2 affinity purified antibody.
Src
We offer many products related to Src for your research needs.
Dopamine, Norepinephrine and Ephinephrine Synthesis
Dopamine-β-hydroxylase is located inside amine storage vesicles of norepinephrine neurons. Dopamine is actively transported from the cytoplasm into the vesicles. As the enzyme is a copper containing protein, its activity can be inhibited by copper chelating agents, such as diethyldithiocarbamate
Prostanoid Receptors
We offer many products related to prostanoid receptors for your research needs.
ISOGRO® Amplify Recombinant Protein Expression
Our company presents an informative page regarding the use of ISOTEC Stable Isotopes to Amplify Recombinant Protein Expression with ISOGRO.
Cholecystokinin and Gastrin Receptors
The naturally occurring peptides, cholecystokinin (CCK) and gastrin closely resemble each other at their carboxyl terminus, which is the biologically active portion of the molecules.
Phosphoinositide Kinases
Sigma-Aldrich offers many products related to phosphoinositide kinases for your research needs.
How Proximity Ligation Assays (PLA) Work
Learn how Proximity Ligation Assay technology works and how the protein-protein interaction control kit can confirm in situ detection of EGF-induced EGFR-HER2 dimerization.
Potassium Channels
We offer many products related to potassium channels for your research needs.
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