Asymmetric phase transfer catalysis using the Maruoka catalysts has proven to be an ideal method for the enantioselective preparation of natural and unnatural α-alkyl and α,α-dialkyl-α-amino acids from glycine derivati
Molecular sieves are crystalline metal aluminosilicates having a threedimensional interconnecting network of silica and alumina tetrahedra. Natural water of hydration is removed from this network by heating to produce uniform cavities which selectively adsorb molecules of a specific size.
The past couple of decades have witnessed a surge in the popularity of allenes as viable building blocks for a wide variety of synthetic applications. Their versatility allows them to participate in nucleophilic and electrophilic additions, cycloadditions and cyclizations, as
Red-Al®, or sodium bis(2-methoxyethoxy)aluminum dihydride (Vitride®, SMEAH), is a versatile reducing agent and a good substitute for LiAlH4 in many reactions. Red-Al® is nonpyrophoric, although still moisture-sensitive, and is available in solution, allowing for easier handling compared to LiAlH4.
Bis(pyridine)iodonium tetrafluoroborate is a mild iodinating and oxidizing reagent capable of selectively reacting with a wide range of unsaturated substrates and tolerates a variety of functional groups.
Benzyl ethers and derivatives are among the most widely used protecting groups in organic synthesis. Cleavage can be effected under a variety of conditions including hydrogenolysis, oxidation, and acid decomposition.
JandaJels are designed to create a “solvent-like organic microenvironment to catalyze organic reactions”. The flexible tetrahydrofuran-like cross-linker gives the JandaJels increased swelling and solvation characteristics as compared to polystyrene resins cross-linked with divinylbenzene.
Due to stricter safety regulations, shipment of diethyl azodicarboxylate (DEAD) as a dry reagent is prohibited in the United States. We have achieved full compliance with UN and U.S. DOT safety regulations, and is pleased to offer this extremely versatile
Prof. James L. Leighton has developed constrained five-membered silacycles. These chiral silane Lewis acid reagents are useful chiral catalysts in enantioselective allylations of simple aldehydes or hydrazones for the preparation of chiral carbinols and carbinamines.
In 2001, Professor William Dolbier, Jr., at the University of Florida reported1 an approach to nucleophilic trifluoromethylation based on the generation of a trifluoromethyl anion using CF3I in the presence of a powerful twoelectron reductant, tetrakis(dimethylamino)ethylene (TDAE)
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