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Palaniappan Seedevi et al.
International journal of biological macromolecules, 72, 1459-1465 (2014-12-03)
Sulfated polysaccharide was isolated from Monostroma oxyspermum through hot water extraction, anion-exchange and gel permeation column chromatography. The sulfated polysaccharide contained 92% of carbohydrate, 0% of protein, 7.8% of uronic acid, 22% of ash and 33% of moisture respectively. The
Adinda Wellens et al.
PloS one, 3(4), e2040-e2040 (2008-05-01)
Escherichia coli strains adhere to the normally sterile human uroepithelium using type 1 pili, that are long, hairy surface organelles exposing a mannose-binding FimH adhesin at the tip. A small percentage of adhered bacteria can successfully invade bladder cells, presumably
Kitti B Kovács et al.
Thrombosis research, 135(4), 718-726 (2015-01-27)
Protein C (PC) is a major anticoagulant and numerous distinct mutations in its coding gene result in quantitative or qualitative PC deficiency with high thrombosis risk. Homozygous or compound heterozygous PC deficiency usually leads to life-threatening thrombosis in neonates. The
Zofia Błach-Olszewska
Archivum immunologiae et therapiae experimentalis, 53(3), 245-253 (2005-07-05)
Essential differences between the innate and acquired branches of immunity are described. These differences concern the detection system (receptors and pathogen structures) and the cells engaged in both systems as well as the effectory mechanisms. In contrast to those of
Scott Wushke et al.
Applied and environmental microbiology, 81(16), 5567-5573 (2015-06-07)
Development of a designed coculture that can achieve aerotolerant ethanogenic biofuel production from cellulose can reduce the costs of maintaining anaerobic conditions during industrial consolidated bioprocessing (CBP). To this end, a strain of Caldibacillus debilis isolated from an air-tolerant cellulolytic
E Maritta Pietilä et al.
The Journal of biological chemistry, 280(28), 26622-26629 (2005-05-20)
Increasing evidence suggests that the folding and maturation of monomeric proteins and assembly of multimeric protein complexes in the endoplasmic reticulum (ER) may be inefficient not only for mutants that carry changes in the primary structure but also for wild
Karen O Dixon et al.
European journal of immunology, 45(6), 1736-1747 (2015-03-31)
IL-35 is a cytokine of the IL-12 family, existing as a heterodimer of IL-12p35 and Ebi3. IL-35 has anti-inflammatory properties and is produced by regulatory T cells in humans and mice, where it is required for optimal suppression of immune
Shinji Go et al.
Glycoconjugate journal, 23(5-6), 411-421 (2006-08-10)
Deaminoneuraminic acid (KDN) is a unique member of the sialic acid family. We previously demonstrated that free KDN is synthesized de novo from mannose as its precursor sugar in trout testis, and that the amount of intracellular KDN increases in
H Wang et al.
Clinical and experimental immunology, 181(3), 518-527 (2015-05-13)
The interaction between neutrophils and activation of alternative complement pathway plays a pivotal role in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). ANCAs activate primed neutrophils to release neutrophil extracellular traps (NETs), which have recently gathered increasing attention
Prithy Rupa et al.
Journal of agricultural and food chemistry, 62(39), 9479-9487 (2014-09-13)
Food allergies are attributed to an imbalance in immune response to ubiquitous antigens. A previous study demonstrated that mannose glycation (mannosylation) of ovalbumin decreased allergenicity in vivo. The proposed research targets mannosylation of various common allergens that may help prevent
Clara Maria Pichl et al.
International journal of pharmaceutics, 495(2), 710-718 (2015-09-19)
Urinary tract infections (UTIs) are among the most common bacterial infections. Despite a wide range of therapeutic options, treatment success is compromised by multiresistance and the efficient mechanism of tissue colonization of uropathogenic Escherichia coli (UPEC). In advanced drug delivery
Meifeng Zhu et al.
Biomaterials, 61, 85-94 (2015-05-23)
An ideal vascular graft should have the ability to guide the regeneration of neovessels with structure and function similar to those of the native blood vessels. Regeneration of vascular smooth muscle cells (VSMCs) with circumferential orientation within the grafts is
Amanda J Stranks et al.
Journal of innate immunity, 7(4), 375-391 (2015-03-15)
Macrophages provide a bridge linking innate and adaptive immunity. An increased frequency of macrophages and other myeloid cells paired with excessive cytokine production is commonly seen in the aging immune system, known as 'inflamm-aging'. It is presently unclear how healthy
I M Sánchez Guiu et al.
Thrombosis and haemostasis, 114(2), 313-324 (2015-05-23)
Platelet cold agglutinins (PCA) cause pseudothrombocytopenia, spurious thrombocytopenia due to ex vivo platelet clumping, complicating clinical diagnosis, but mechanisms and consequences of PCA are not well defined. Here, we characterised an atypical immunoglobulin (Ig)M PCA in a 37-year-old woman with
Gillian H Dean et al.
Bio-protocol, 9(24), e3464-e3464 (2019-12-20)
Arabidopsis seed coat epidermal cells deposit a significant quantity of mucilage, composed of the cell wall components pectin, hemicellulose, and cellulose, into the apoplast during development. When mature seeds are hydrated, mucilage extrudes to form a gelatinous capsule around the
Ronan Euzen et al.
Bioorganic & medicinal chemistry, 19(9), 2879-2887 (2011-04-13)
We described herein the synthesis of second generation glycopeptide dendrimers G2a-g presenting variable amino acids placed internally into the multivalent scaffold. The effect of such structural modulation on recognition processes by Concanavalin A (Con A), was then estimated by enhanced-sensitivity
Rui Xie et al.
Bioresource technology, 186, 106-113 (2015-03-31)
Carbonyl compounds generated in biomass pretreatment hinder the biochemical conversion of biomass hydrolysates to biofuels. A novel approach of detoxifying hydrolysates with amino acids for ethanol production was developed. Among the 20 amino acids assessed for their detoxification efficiency and
Xiaoying Lei et al.
Scientific reports, 5, 7824-7824 (2015-01-17)
The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection
Ulrike Harre et al.
Nature communications, 6, 6651-6651 (2015-04-01)
Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the engagement of pro- or anti-inflammatory Fcγ receptors (FcγR) and the direction of the immune response. Whether IgG sialylation influences osteoclast differentiation and subsequently bone architecture has not been determined
Cosmin S Voican et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(3), 967-978 (2014-04-29)
Patients with alcoholic liver disease (ALD) display inflammation of the subcutaneous adipose tissue (SAT) which correlates with liver lesions. We examined macrophage markers and polarization in the SAT of alcoholic patients and adipokine expression according to liver inflammation; we studied
Charlotte Roma-Lavisse et al.
Diabetes & vascular disease research, 12(4), 279-289 (2015-05-15)
This study aimed to investigate atherosclerotic mediators' expression levels in M1 and M2 macrophages and to focus on the influence of diabetes on M1/M2 profiles. Macrophages from 36 atherosclerotic patients (19 diabetics and 17 non-diabetics) were cultured with interleukin-1β (IL-1β)
Anna Sipos et al.
Tuberculosis (Edinburgh, Scotland), 95 Suppl 1, S200-S206 (2015-03-25)
Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find novel antitubercular agents several approaches have been used in various institutions worldwide, including target-based approaches against several validated mycobacterial enzymes
Michal Babič et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(6), 1141-1148 (2014-10-07)
Coprecipitation of FeCl2 and FeCl3 with aqueous ammonia was used to prepare iron oxide nanoparticles dispersible in aqueous medium. Oxidation of the particles with sodium hypochlorite then yielded maghemite (γ-Fe2 O3 ) nanoparticles which were coated with two types of
Tsung-Lin Cheng et al.
The Journal of investigative dermatology, 135(6), 1668-1675 (2015-02-05)
Keratinocyte-expressed thrombomodulin (TM) and the released soluble TM (sTM) have been demonstrated to promote wound healing. However, the effects of high glucose on TM expression in keratinocytes and the role of TM in diabetic ulcer remain unclear. In this study
Guochuang Chen et al.
Carbohydrate polymers, 121, 107-114 (2015-02-11)
The aim of this study was to investigate the anticancer activity of exopolysaccharide (PEP) of Antarctic bacterium Pseudoaltermonas sp. S-5 and elucidate the underlying molecular mechanisms. PEP significantly inhibited the growth of human leukemia K562 cells. Results of morphological characterization
Sanja Milkovska-Stamenova et al.
Journal of agricultural and food chemistry, 63(25), 5911-5919 (2015-06-06)
Glycation is a ubiquitous nonenzymatic reaction of carbonyl compounds with amino groups of peptides and proteins, resulting in the formation of advanced glycation end-products (AGEs) and thereby affecting the properties and quality of thermally processed foods. In this context, mechanisms
Santosh K Patnaik et al.
The Journal of biological chemistry, 280(21), 20851-20859 (2005-03-25)
The human LARGE gene encodes a protein with two putative glycosyltransferase domains and is required for the generation of functional alpha-dystroglycan (alpha-DG). Monoclonal antibodies IIH6 and VIA4-1 recognize the functional glycan epitopes of alpha-DG that are necessary for binding to
Xue-Qiang Zha et al.
International journal of biological macromolecules, 78, 429-438 (2015-05-03)
In the present study, a new water-soluble polysaccharide (LJP-11) was obtained from Laminaria japonica by anion exchange DEAE-cellulose chromatography and Sephacryl S-500 chromatography. The average molecular weight of this polysaccharide was estimated to be about 2.89×10(6) Da by high performance
Bryan R Conway et al.
Nephrology (Carlton, Vic.), 19(12), 802-813 (2014-09-10)
Regression of albuminuria and renal fibrosis occurs in patients with diabetic nephropathy (DN) following tight control of blood glucose and blood pressure, however the pathways that promote regression remain poorly understood and we wished to characterize these using a rodent
Jeong Heo Kwon et al.
Bioresource technology, 199, 283-287 (2015-09-16)
A facile butanol bioproduction process was developed using planetary milling, and Pinus rigida wood waste as a model substrate for fermentable sugars. The use of planetary milling as the pretreatment eliminates the need for washing and transfer of the biomass
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