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Xiao-Liang Zhang et al.
Endocrinology, 155(12), 4939-4950 (2014-09-05)
Increasing evidence suggests the heterogeneity of macrophage phenotype and function ultimately determines the outcome of diabetic nephropathy (DN). This study aimed to investigate the effects of vitamin D on macrophage M1/M2 phenotype and its role in preventing podocyte impairment in...
D L Jack et al.
Immunological reviews, 180, 86-99 (2001-06-21)
Mannose-binding lectin (MBL) is an important constituent of the innate immune system. This protein binds through multiple lectin domains to the repeating sugar arrays that decorate many microbial surfaces, and is then able to activate the complement system through a...
Laura C Whitmore et al.
American journal of physiology. Lung cellular and molecular physiology, 307(1), L71-L82 (2014-05-06)
Systemic inflammatory response syndrome (SIRS) is a common clinical condition in patients in intensive care units that can lead to complications, including multiple organ dysfunction syndrome (MODS). MODS carries a high mortality rate, and it is unclear why some patients...
Marian Wenzel et al.
Microbiology (Reading, England), 161(10), 1942-1949 (2015-08-05)
To optimize Bacillus subtilis as a production strain for proteins and low molecular substances by genome engineering, we developed a markerless gene deletion system. We took advantage of a general property of the phosphoenolpyruvate-dependent phosphotransferase system (PTS), in particular the...
Gao-Jian Jing et al.
IET systems biology, 9(4), 147-154 (2015-08-06)
This study proposes a gene link-based method for survival time-related pathway hunting. In this method, the authors incorporate gene link information to estimate how a pathway is associated with cancer patient's survival time. Specifically, a gene link-based Cox proportional hazard...
K Aydogan et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 28(10), 1306-1312 (2013-10-15)
Several genes encoding different Th1 and Th2 cytokines may play crucial roles in host susceptibility to Condyloma acuminatum (CA). Mannose-binding lectin (MBL) is a serum lectin that mediates complement activation, and it is a member of innate immune system. MBL...
Yuan Yue et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 76-84 (2014-09-27)
The polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp (PWJS) is evaluated for the chemical composition, antioxidant activity and hepatoprotective effect. The characteristics of PWJS were determined by FT-IR spectral and HPLC analysis. The...
Zhichao Pei et al.
Bioorganic & medicinal chemistry letters, 15(11), 2707-2710 (2005-05-10)
Glycosyldisulfides can interact efficiently with carbohydrate-binding entities. This has been shown for a range of thiosaccharide dimers when tested for their effects against the lectin Concanavalin A using a modified quartz crystal microbalance-technique. Contrary to the thiosaccharide monomers, showing no...
Elsa Petit et al.
PloS one, 10(6), e0118285-e0118285 (2015-06-04)
Clostridium phytofermentans was isolated from forest soil and is distinguished by its capacity to directly ferment plant cell wall polysaccharides into ethanol as the primary product, suggesting that it possesses unusual catabolic pathways. The objective of the present study was...
M R Bürk et al.
Placenta, 22(4), 309-316 (2001-04-05)
Pre-eclampsia is a disorder of unknown aetiology peculiar to human pregnancy. A well-described pathological feature being shallow trophoblast invasion into the spiral arteries during placenta development. Epidemiological studies have revealed an increased risk in pregnancies of primipaternity, and an association...
Essentials of Carbohydrate Chemistry by John F. Robyt
Pendarvis R
The Chemical Educator, 3(5), 1-2 (1998)
Na Kong et al.
Carbohydrate research, 405, 33-38 (2015-03-10)
Carbohydrate-functionalized single-walled carbon nanotubes (SWNTs) were synthesized using microwave-assisted reaction of perfluorophenyl azide with the nanotubes. The results showed that microwave radiation provides a rapid and effective means to covalently attach carbohydrates to SWNTs, producing carbohydrate-SWNT conjugates for biorecognition. The...
Ana Sofia Carvalho et al.
Molecular & cellular proteomics : MCP, 13(12), 3294-3307 (2014-08-17)
We investigated the molecular effects of glucosamine supplements, a popular and safe alternative to nonsteroidal anti-inflammatory drugs, for decreasing pain, inflammation, and maintaining healthy joints. Numerous studies have reported an array of molecular effects after glucosamine treatment. We questioned whether...
M M Brysk et al.
The Journal of investigative dermatology, 82(3), 280-282 (1984-03-01)
A mannose-containing 40K glycoprotein has been identified in the stratum corneum of normal human epidermis. It is apparently membrane-bound and in the intact epidermis it is inaccessible to either concanavalin A or to trypsin. After it is detergent-solubilized, it can...
Determination of D-mannose in serum by capillary electrophoresis.
H A Carchon et al.
Clinical chemistry, 47(7), 1319-1321 (2001-06-28)
Zhen Huang et al.
Biomaterials, 48, 26-36 (2015-02-24)
Tumor necrosis factor-alpha (TNF-α) plays a central role in the pathogenesis of inflammatory bowel disease (IBD). Anti-TNF-α therapies have shown protective effects against colitis, but an efficient tool for target suppression of its secretion - ideally via oral administration -...
Bei Zhang et al.
Journal of neuroinflammation, 12, 218-218 (2015-11-26)
Macrophages persist indefinitely at sites of spinal cord injury (SCI) and contribute to both pathological and reparative processes. While the alternative, anti-inflammatory (M2) phenotype is believed to promote cell protection, regeneration, and plasticity, pro-inflammatory (M1) macrophages persist after SCI and...
Shigeyuki Tsutsui et al.
Journal of biochemistry, 157(5), 345-356 (2014-12-01)
The aim of this study was to determine the physiological role of skin lectins of the Japanese bullhead shark (Heterodontus japonicus). A skin extract was subjected to affinity chromatography using seven different sugars as ligands. Molecular mass and N-terminal amino...
Noriko Ishii et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 5118-5128 (2014-10-10)
Nucleic acid-sensing TLRs are involved in both antimicrobial immune responses and autoimmune inflammation. TLR8 is phylogenetically and structurally related to TLR7 and TLR9, which undergo proteolytic processing in the endolysosomes to generate functional receptors. Recent structural analyses of human TLR8...
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio...
Golgi glycosylation
Stanley P
Cold Spring Harbor Perspectives in Biology, 3(4), a005199-a005199 (2011)
Hua-Li Tang et al.
International journal of biological macromolecules, 77, 235-242 (2015-03-31)
Purification, characterization and hypoglycemic activities of polysaccharide from Lycium barbarum L. were investigated in this study. A water soluble polysaccharide (LBP) was obtained with ultrafiltration membranes separation, which was further purified by chromatography of DEAE cellulose column and Sephadex G-150...
M A Bartlomiejczyk et al.
Clinical and experimental immunology, 178(2), 310-319 (2014-07-22)
We have demonstrated that mannose-binding lectin (MBL) recognizes various slow-growing, pathogenic mycobacteria [Mycobacterium tuberculosis (MTB), M. bovis, M. kansasii, M. gordonae] as well as non-pathogenic M. smegmatis. Recognition resulted in activation of the lectin pathway (LP) of complement and an enhancement of phagocytosis (shown for...
Charlotte Roma-Lavisse et al.
Diabetes & vascular disease research, 12(4), 279-289 (2015-05-15)
This study aimed to investigate atherosclerotic mediators' expression levels in M1 and M2 macrophages and to focus on the influence of diabetes on M1/M2 profiles. Macrophages from 36 atherosclerotic patients (19 diabetics and 17 non-diabetics) were cultured with interleukin-1β (IL-1β)...
Xue-Qiang Zha et al.
International journal of biological macromolecules, 78, 429-438 (2015-05-03)
In the present study, a new water-soluble polysaccharide (LJP-11) was obtained from Laminaria japonica by anion exchange DEAE-cellulose chromatography and Sephacryl S-500 chromatography. The average molecular weight of this polysaccharide was estimated to be about 2.89×10(6) Da by high performance...
E Maritta Pietilä et al.
The Journal of biological chemistry, 280(28), 26622-26629 (2005-05-20)
Increasing evidence suggests that the folding and maturation of monomeric proteins and assembly of multimeric protein complexes in the endoplasmic reticulum (ER) may be inefficient not only for mutants that carry changes in the primary structure but also for wild...
J S Rush et al.
Glycobiology, 10(8), 829-835 (2000-08-06)
Congenital Disorders of Glycosylation (CDG) are human deficiencies in glycoprotein biosynthesis. Previous studies showed that 1 mM mannose corrects defective protein N-glycosylation in cultured fibroblasts from some CDG patients. We hypothesized that these CDG cells have limited GDP-mannose (GDP-Man) and...
Karen O Dixon et al.
European journal of immunology, 45(6), 1736-1747 (2015-03-31)
IL-35 is a cytokine of the IL-12 family, existing as a heterodimer of IL-12p35 and Ebi3. IL-35 has anti-inflammatory properties and is produced by regulatory T cells in humans and mice, where it is required for optimal suppression of immune...
Scott Wushke et al.
Applied and environmental microbiology, 81(16), 5567-5573 (2015-06-07)
Development of a designed coculture that can achieve aerotolerant ethanogenic biofuel production from cellulose can reduce the costs of maintaining anaerobic conditions during industrial consolidated bioprocessing (CBP). To this end, a strain of Caldibacillus debilis isolated from an air-tolerant cellulolytic...
Juha P Kotimaa et al.
Journal of immunological methods, 419, 25-34 (2015-03-04)
The complement system is an essential component of our innate immunity, both for the protection against infections and for proper handling of dying cells. However, the complement system can also contribute to tissue injury and inflammatory responses. In view of...
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