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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.

R Zufferey et al.

Nature biotechnology, 15(9), 871-875 (1997-11-05)

Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vivo delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages.

Courtney G Woods et al.

Toxicology and applied pharmacology, 238(1), 27-36 (2009-04-21)

Hypochlorous acid (HOCl) is potentially an important source of cellular oxidative stress. Human HOCl exposure can occur from chlorine gas inhalation or from endogenous sources of HOCl, such as respiratory burst by phagocytes. Transcription factor Nrf2 is a key regulator

Chemokine: receptor structure, interactions, and antagonism.

Samantha J Allen et al.

Annual review of immunology, 25, 787-820 (2007-02-13)

Chemokines are critical mediators of cell migration during routine immune surveillance, inflammation, and development. Chemokines bind to G protein-coupled receptors and cause conformational changes that trigger intracellular signaling pathways involved in cell movement and activation. Although chemokines evolved to benefit

Lentivirus-delivered stable gene silencing by RNAi in primary cells.

Sheila A Stewart et al.

RNA (New York, N.Y.), 9(4), 493-501 (2003-03-22)

Genome-wide genetic approaches have proven useful for examining pathways of biological significance in model organisms such as Saccharomyces cerevisiae, Drosophila melanogastor, and Caenorhabditis elegans, but similar techniques have proven difficult to apply to mammalian systems. Although manipulation of the murine

Retinoid and thiazolidinedione therapies in melanoma: an analysis of differential response based on nuclear hormone receptor expression.

Joshua P Klopper et al.

Molecular cancer, 8, 16-16 (2009-03-10)

Metastatic melanoma has a high mortality rate and suboptimal therapeutic options. Molecular targeting may be beneficial using the rexinoid LGD1069, a retinoid x receptor selective agonist, and thiazolidinediones (TZD), PPARgamma selective ligands, as novel treatments. Mouse xenograft models with human

Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation.

Céline Callewaere et al.

Journal of molecular endocrinology, 38(3), 355-363 (2007-03-07)

Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells both in vivo and in vitro. In addition to their well-established role in the immune system, several recent reports have suggested that chemokines and their receptors may

Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells.

J C Burns et al.

Proceedings of the National Academy of Sciences of the United States of America, 90(17), 8033-8037 (1993-09-01)

The restricted host-cell range and low titer of retroviral vectors limit their use for stable gene transfer in eukaryotic cells. To overcome these limitations, we have produced murine leukemia virus-derived vectors in which the retroviral envelope glycoprotein has been completely

The many roles of chemokines and chemokine receptors in inflammation.

Israel F Charo et al.

The New England journal of medicine, 354(6), 610-621 (2006-02-10)

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