Dhanoop Manikoth Ayyathan et al.
Journal of enzyme inhibition and medicinal chemistry, 36(1), 401-409 (2021-01-13)
The C2-WW-HECT-domain E3 ubiquitin ligase SMURF2 emerges as an important regulator of diverse cellular processes. To date, SMURF2-specific modulators were not developed. Here, we generated and investigated a set of SMURF2-targeting synthetic peptides and peptidomimetics designed to stimulate SMURF2's autoubiquitination