- Effects of the components of hormone therapy on matrix metalloproteinases in breast-cancer cells: an in vitro study.
Effects of the components of hormone therapy on matrix metalloproteinases in breast-cancer cells: an in vitro study.
Fertility and sterility (2007-01-09)
Maher A Abdallah, Huda I Abdullah, Steven Kang, Douglas D Taylor, Steven T Nakajima, Cicek Gercel-Taylor
PMID17207794
ABSTRACT
A combination of E and progestogens significantly increased matrix metalloproteinase (MMP)-2 in both T47D cells (E(2)-medroxyprogesteroneacetate [MPA] and E(2)-P) and MCF-7 cells (E(2)-MPA, E(2)-P, and equilin-MPA). All combinations resulted in higher MMP-9 levels in MCF-7 cells, but higher MMP-9 levels resulted only with equilin-norethinderone in T47D cells.
MATERIALS