- Synthesis of phenothiazines via ligand-free CuI-catalyzed cascade C-S and C-N coupling of aryl ortho-dihalides and ortho-aminobenzenethiols.
Synthesis of phenothiazines via ligand-free CuI-catalyzed cascade C-S and C-N coupling of aryl ortho-dihalides and ortho-aminobenzenethiols.
Chemical communications (Cambridge, England) (2012-04-25)
Chuan Dai, Xiaofei Sun, Xingzhao Tu, Li Wu, Dan Zhan, Qingle Zeng
PMID22525793
ABSTRACT
A ligand-free CuI-catalyzed cascade C-S and C-N cross coupling of (hetero)aryl ortho-dihalides and ortho-aminobenzenethiols has been developed, and various phenothiazines were synthesized with excellent regioselectivity. A possible mechanism is proposed for the cascade coupling.
MATERIALS
Product Number
Brand
Product Description