- Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid.
Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid.
Die Pharmazie (2012-08-15)
J Rojas, V Kumar
PMID22888514
ABSTRACT
Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug release than MCCI-based pellets. MCCII-based pellets showed an immediate diphenydramineHCl release profile comparable to that of Benadryl and a faster griseofulvin release than MCCI-based pellets. MCCII offers potential to use as an alternative pelletization aid.
MATERIALS
Product Number
Brand
Product Description
Diphenhydramine hydrochloride, European Pharmacopoeia (EP) Reference Standard
Supelco
Diphenhydramine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Diphenhydramine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®