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Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.

Organic & biomolecular chemistry (2012-11-08)
Rania M Deranieh, Miriam L Greenberg, Pierre-B Le Calvez, Maura C Mooney, Marie E Migaud
PMID23132282
ABSTRACT

The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

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