- Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade.
Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade.
Organic letters (2003-06-21)
Lori A Maggio-Hall, Pieter C Dorrestein, Jorge C Escalante-Semerena, Tadhg P Begley
PMID12816411
ABSTRACT
Dimethylbezimidazole, the axial ligand of vitamin B(12), is synthesized from riboflavin by a two-electron oxidation, a retro-aldol condensation, and a second two-electron oxidation. This oxidative cascade readily takes place nonenzymatically under physiological conditions. [reaction: see text]
MATERIALS