Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Dalton transactions (Cambridge, England : 2003) (2012-08-15)

Živadin D Bugarčić, Jovana Bogojeski, Biljana Petrović, Stephanie Hochreuther, Rudi van Eldik

ABSTRACT

A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.

MATERIALS

Product Number

Brand

Product Description

GF54506178

Platinum, foil, 0.1m coil, thickness 0.025mm, coil width 1.2mm, as rolled, 99.95%

GF90635317

Platinum, foil, 0.05m coil, thickness 0.045mm, coil width .75mm, as rolled, 99.95%

GF68919889

Platinum, foil, 15mm disks, thickness 0.0075mm, as rolled, 99.95%

GF57062550

Platinum, foil, 0.1m coil, thickness 0.2mm, coil width 5mm, as rolled, 99.95%

GF53370378

Platinum, wire reel, 0.2m, diameter 0.005mm, wollaston, 99.9%

GF06852900

Platinum, wire reel, 0.2m, diameter 0.006mm, wollaston, 99.9%

GF00548917

Platinum, foil, not light tested, 25x25mm, thickness 0.003mm, as rolled, 99.95%

GF31165118

Platinum, wire reel, 0.5m, diameter 0.40mm, as drawn, 99.99%

GF29522101

Platinum, foil, 10mm disks, thickness 0.01mm, as rolled, 99.95%

GF56820157

Platinum, foil, 4mm disks, thickness 0.0125mm, as rolled, 99.95%

GF69463480

Platinum, foil, not light tested, 50x50mm, thickness 0.0005mm, permanent polyester support, 99.85%

GF71917005

Platinum, foil, 0.1m coil, thickness 0.025mm, coil width 8mm, as rolled, 99.95%

GF13257222

Platinum, foil, 15mm disks, thickness 0.0125mm, as rolled, 99.95%

GF94151257

Platinum, wire reel, 0.5m, diameter 0.25mm, as drawn, 99.998%

GF02026965

Platinum, wire reel, 0.1m, diameter 0.005mm, wollaston, 99.9%

GF65307090

Platinum, foil, 8mm disks, thickness 0.125mm, as rolled, 99.99+%

GF37181853

Platinum, foil, 0.2m coil, thickness 0.025mm, coil width .85mm, as rolled, 99.95%

GF93174318

Platinum, wire reel, 10m, diameter 0.05mm, annealed, may be used as one component of a thermocouple, 99.99%

GF14986109

Platinum, foil, 25mm disks, thickness 0.0075mm, as rolled, 99.95%

GF31105864

Platinum, foil, 10mm disks, thickness 0.025mm, as rolled, 99.95%

GF58445433

Platinum, foil, 0.2m coil, thickness 0.125mm, coil width 2.5mm, as rolled, 99.99%

GF04625355

Platinum, wire reel, 0.2m, diameter 0.25mm, as drawn, 99.99+%

GF49364264

Platinum, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

GF56319699

Platinum, wire reel, 0.5m, diameter 0.25mm, hard, 99.95%

GF97027443

Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 1.2mm, as rolled, 99.95%

GF88763631

Platinum, wire reel, 0.2m, diameter 0.125mm, annealed, may be used as one component of a thermocouple, 99.99%

GF34217276

Platinum, foil, 15mm disks, thickness 0.05mm, as rolled, 99.95%

GF14510359

Platinum, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.95%

GF32643154

Platinum, wire reel, 0.2m, diameter 0.5mm, as drawn, 99.99+%

GF59961594

Platinum, wire reel, 0.5m, diameter 0.05mm, annealed, may be used as one component of a thermocouple, 99.99%