DNA-damage repair; the good, the bad, and the ugly.

The EMBO journal (2008-02-21)
Razqallah Hakem
ABSTRACT

Organisms have developed several DNA-repair pathways as well as DNA-damage checkpoints to cope with the frequent challenge of endogenous and exogenous DNA insults. In the absence or impairment of such repair or checkpoint mechanisms, the genomic integrity of the organism is often compromised. This review will focus on the functional consequences of impaired DNA-repair pathways. Although each pathway is addressed individually, it is essential to note that cross talk exists between repair pathways, and that there are instances in which a DNA-repair protein is involved in more than one pathway. It is also important to integrate DNA-repair process with DNA-damage checkpoints and cell survival, to gain a better understanding of the consequences of compromised DNA repair at both cellular and organismic levels. Functional consequences associated with impaired DNA repair include embryonic lethality, shortened life span, rapid ageing, impaired growth, and a variety of syndromes, including a pronounced manifestation of cancer.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
MISSION® shRNA Human Gene Family Set, Lentiviral Particles, DNA Repair Pathway
Sigma-Aldrich
MISSION® shRNA Human Gene Family Set, DNA, DNA Repair Pathway
Sigma-Aldrich
MISSION® shRNA Human Gene Family Set, Bacterial Glycerol Stock, DNA Repair Pathway