ASPH
aspartate beta-hydroxylase
Synonimy:
AAH, BAH, CASQ2BP1, HAAH, JCTN, junctin
Gatunek:
Human ASPH (444), Mouse Asph (65973), Rat Asph (312981), domestic cat ASPH (101100695), dog ASPH (403846), naked mole-rat Asph (101725986), Zebrafish asph (323659), cow ASPH (286771), domestic guinea pig Asph (100726813), Horse ASPH (100065909) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(444) Summary: This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
- Mouse(65973) aspartate-beta-hydroxylase
- Rat(312981) aspartate-beta-hydroxylase
- domestic cat(101100695) aspartate beta-hydroxylase
- dog(403846) aspartate beta-hydroxylase
- naked mole-rat(101725986) aspartate beta-hydroxylase
- Zebrafish(323659) aspartate beta-hydroxylase
- cow(286771) aspartate beta-hydroxylase
- domestic guinea pig(100726813) aspartate beta-hydroxylase
- Horse(100065909) aspartate beta-hydroxylase
- chicken(421142) aspartate beta-hydroxylase
- fruit fly(36778) Aspartyl beta-hydroxylase
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-ASPH, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-ASPH, affinity isolated antibody,
Reaktywność gatunkowa
dog, human, rat
Zastosowanie
western blot
Anti-ASPH antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry