DCLK1
doublecortin-like kinase 1
Synonimy:
CL1, CLICK1, DCAMKL1, DCDC3A, DCLK
Gatunek:
Human DCLK1 (9201), Mouse Dclk1 (13175), Rat Dclk1 (83825), naked mole-rat Dclk1 (101719985), cow DCLK1 (613449), chicken DCLK1 (418903), sheep DCLK1 (101106340), Horse DCLK1 (100062396), dog DCLK1 (477304), domestic cat DCLK1 (101083643)
Identyfikator UniProtKB:
Identyfikator genu:
- Human(9201) Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
- Mouse(13175) doublecortin-like kinase 1
- Rat(83825) doublecortin-like kinase 1
- naked mole-rat(101719985) doublecortin-like kinase 1
- cow(613449) doublecortin-like kinase 1
- chicken(418903) doublecortin-like kinase 1
- sheep(101106340) doublecortin-like kinase 1
- Horse(100062396) doublecortin-like kinase 1
- dog(477304) doublecortin-like kinase 1
- domestic cat(101083643) doublecortin-like kinase 1
- domestic guinea pig(100725335) doublecortin-like kinase 1
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Monoclonal Anti-DCAMKL1, (C-terminal) antibody produced in mouse, clone 6H4, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human, mouse
Zastosowanie
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-DCLK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
Anty-DCLK1-S, from rabbit,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
Anty-DCLK1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
ANTI-DCAMKL1(N-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reaktywność gatunkowa
human, mouse
Zastosowanie
western blot