DUSP10
dual specificity phosphatase 10
Synonimy:
MKP-5, MKP5
Gatunek:
Human DUSP10 (11221), Mouse Dusp10 (63953), Rat Dusp10 (63995), Domestic Rabbit DUSP10 (100352279), naked mole-rat Dusp10 (101715205), domestic cat DUSP10 (101096697), Horse DUSP10 (100050108), domestic guinea pig Dusp10 (100733434), sheep DUSP10 (101106025), dog DUSP10 (488673) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(11221) Summary: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(63953) dual specificity phosphatase 10
- Rat(63995) dual specificity phosphatase 10
- Domestic Rabbit(100352279) dual specificity phosphatase 10
- naked mole-rat(101715205) dual specificity phosphatase 10
- domestic cat(101096697) dual specificity phosphatase 10
- Horse(100050108) dual specificity phosphatase 10
- domestic guinea pig(100733434) dual specificity phosphatase 10
- sheep(101106025) dual specificity phosphatase 10
- dog(488673) dual specificity phosphatase 10
- chicken(421340) dual specificity phosphatase 10
- cow(541175) dual specificity phosphatase 10
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-DUSP10 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry
immunohistochemistry