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EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3

Synonimy:
PEK, PERK, WRS
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(9451) Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]
  • Mouse(13666) eukaryotic translation initiation factor 2 alpha kinase 3
  • Rat(29702) eukaryotic translation initiation factor 2 alpha kinase 3
  • Horse(100066488) eukaryotic translation initiation factor 2-alpha kinase 3
  • domestic cat(101095973) eukaryotic translation initiation factor 2-alpha kinase 3
  • cow(535820) eukaryotic translation initiation factor 2-alpha kinase 3
  • Zebrafish(559564) eukaryotic translation initiation factor 2-alpha kinase 3
  • dog(475756) eukaryotic translation initiation factor 2-alpha kinase 3
  • chicken(422930) eukaryotic translation initiation factor 2-alpha kinase 3
  • sheep(101110042) eukaryotic translation initiation factor 2-alpha kinase 3
  • domestic guinea pig(100725836) eukaryotic translation initiation factor 2-alpha kinase 3
  • naked mole-rat(101713561) eukaryotic translation initiation factor 2-alpha kinase 3

Custom & Knockdown Gene Products

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-E2AK3 antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
immunofluorescence

western blot
Przeciwciało anty-PERK, klon 4F6.1, clone 4F6.1, from mouse,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
Anti-phospho-PEK/PERK (pThr981) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
Anti-EIF2AK3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
Przeciwciało anty-fosfo-PERK-T982wytwarzane u królika, ,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
western blot

Cell Lines

Numer produktu
Opis
Gatunek
HepaRG Komórki PERK (-/-), one vial,
Gatunek
human

Proteins

Numer produktu
Opis
Gatunek
EIF2AK3 (563-1115), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Gatunek
human
PEK, aktywny, ,
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human EIF2AK3, AC104134.2,
Gatunek
human
MISSION® esiRNA, targeting mouse Eif2ak3,
Gatunek
mouse