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Merck

GRIN2B

glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Synonimy:
GluN2B, MRD6, NMDAR2B, NR2B, hNR3
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(2904) Summary: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
  • Mouse(14812) glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • Rat(24410) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • cow(537804) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • dog(494009) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • chicken(417965) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • naked mole-rat(101723091) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic guinea pig(100731840) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • Horse(100063746) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic cat(101094356) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • sheep(101118179) glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numer produktu
Opis
Gatunek
Reversin 205, ≥98% (HPLC), film,
Gatunek
mouse, rat, human
D-Cycloserine, synthetic,
Gatunek
human
Dextromethorphan hydrobromide monohydrate, ≥99% (TLC),
Gatunek
human
N-Methyl-D-aspartic acid, ≥98% (TLC), solid,
Gatunek
human, rat
(S)-AMPA, ≥97%,
Gatunek
mouse, human, rat

Small Molecule - Allosteric Modulator

Numer produktu
Opis
Gatunek
(±)-Ketamine hydrochloride, solid,
Gatunek
human
Ketamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Gatunek
human
S-(+)-Ketamine hydrochloride, ,
Gatunek
human
Ketamine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
Acamprosate calcium, British Pharmacopoeia (BP) Reference Standard,
Gatunek
human

Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
DL-2-Aminoadipic acid, ≥99%,
Gatunek
rat
Ro 8-4304, solid,
Gatunek
human
2-Phenylquinoline, 99%,
Gatunek
rat
Ro 25-6981 hydrochloride hydrate, ≥98% (HPLC), powder,
Gatunek
human
Spermine, suitable for cell culture, BioReagent,
Gatunek
rat, human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Przeciwciało anty-NMDAR2B fosfo Tyr1252, Chemicon®, from rabbit,
Reaktywność gatunkowa
rat
Zastosowanie
western blot
Anti-NMDAR2B Antibody, pain, serum, Chemicon®,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunoprecipitation (IP)
western blot
Przeciwciało anty-NMDAR2B fosfotyrozyna 1336, Chemicon®, from rabbit,
Reaktywność gatunkowa
rat
Zastosowanie
western blot
Anti-GRIN2B (Ab-1474) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunofluorescence
Anti-phospho-GRIN2B (pSer1303) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
western blot

Small Molecule - Blocker

Numer produktu
Opis
Gatunek
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Gatunek
human
Agmatine sulfate salt, ≥97%, powder,
Gatunek
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Gatunek
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
Pentamidine isethionate salt, powder,
Gatunek
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Gatunek
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Gatunek
rat, human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human GRIN2B,
Gatunek
human
MISSION® esiRNA, targeting mouse Grin2b,
Gatunek
mouse