INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
Synonimy:
SHIP, SHIP-1, SHIP1, SIP-145, hp51CN
Gatunek:
Human INPP5D (3635), Mouse Inpp5d (16331), Rat Inpp5d (54259), chicken INPP5D (424745), Zebrafish inpp5d (559103), naked mole-rat Inpp5d (101711777), domestic guinea pig Inpp5d (100722743), sheep INPP5D (101112941), Horse INPP5D (100064896), cow INPP5D (507329) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(3635) Summary: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Mouse(16331) inositol polyphosphate-5-phosphatase D
- Rat(54259) inositol polyphosphate-5-phosphatase D
- chicken(424745) inositol polyphosphate-5-phosphatase, 145kDa
- Zebrafish(559103) inositol polyphosphate-5-phosphatase, 145kDa
- naked mole-rat(101711777) inositol polyphosphate-5-phosphatase, 145kDa
- domestic guinea pig(100722743) inositol polyphosphate-5-phosphatase, 145kDa
- sheep(101112941) inositol polyphosphate-5-phosphatase, 145kDa
- Horse(100064896) inositol polyphosphate-5-phosphatase, 145kDa
- cow(507329) inositol polyphosphate-5-phosphatase, 145kDa
- domestic cat(101100500) inositol polyphosphate-5-phosphatase, 145kDa
- dog(100688270) inositol polyphosphate-5-phosphatase, 145kDa
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anty-INPP5D, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anty-SHIP1, ,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunohistochemistry
western blot
western blot
Anti-phospho-SHIP1 (pTyr1021) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
western blot
western blot
Przeciwciało anty-SHIP1, from rabbit, purified by affinity chromatography,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
Przeciwciało anty-fosfo-INPP5D-Y1020wytwarzane u królika, ,
Reaktywność gatunkowa
human
Zastosowanie
western blot
esiRNA
Numer produktu
Opis
Gatunek