LIMK1
LIM domain kinase 1
Synonimy:
LIMK, LIMK-1
Gatunek:
Human LIMK1 (3984), Mouse Limk1 (16885), Rat Limk1 (65172), domestic cat LIMK1 (101097861), Domestic Rabbit LIMK1 (100344018), dog LIMK1 (489800), Horse LIMK1 (100062100), naked mole-rat Limk1 (101698555), domestic guinea pig Limk1 (100712921), chicken LIMK1 (373922) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(3984) Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
- Mouse(16885) LIM-domain containing, protein kinase
- Rat(65172) LIM domain kinase 1
- domestic cat(101097861) LIM domain kinase 1
- Domestic Rabbit(100344018) LIM domain kinase 1
- dog(489800) LIM domain kinase 1
- Horse(100062100) LIM domain kinase 1
- naked mole-rat(101698555) LIM domain kinase 1
- domestic guinea pig(100712921) LIM domain kinase 1
- chicken(373922) LIM domain kinase 1
- fruit fly(32207) LIM-kinase1
- sheep(101110900) LIM domain kinase 1
- cow(535225) LIM domain kinase 1
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti LIMK1 Antibody, clone 23GB6425, Rabbit Monoclonal, clone 23GB6425, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reaktywność gatunkowa
human
Zastosowanie
western blot
Anti-LIMK1 Antibody, clone 2E21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot
Przeciwciało anty-LIMK1, klon 40/00-1B11-1-1, clone 40/00-1B11-1-1, from rat,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Proteins
Numer produktu
Opis
Gatunek
Białko kinazy LIM 1, aktywne, 10 µg, Active, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638, for use in Kinase Assays.,
Gatunek
human
Białko kinazy LIM 1, nieaktywne, 50 g, Unactive, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638. For use in Kinase Assays.,
Gatunek
human
esiRNA
Numer produktu
Opis
Gatunek