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Merck

LMNA

lamin A/C

Synonimy:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(4000) Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
  • Mouse(16905) lamin A
  • Rat(60374) lamin A/C
  • domestic guinea pig(100735212) lamin A/C
  • chicken(415464) lamin A/C
  • sheep(101107924) lamin A/C
  • cow(404144) lamin A/C
  • domestic cat(101086199) lamin A/C
  • Horse(100057663) lamin A/C
  • dog(480124) lamin A/C
  • Zebrafish(195815) lamin A
  • naked mole-rat(101704567) lamin A/C

Custom & Knockdown Gene Products

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-Lamin A antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-LMNA antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
Anti-Prelamin-A Antibody, clone 7G11, clone 7G11, from rat,
Reaktywność gatunkowa
mouse
Zastosowanie
immunofluorescence
western blot
Przeciwciało anty-lamina A/C, klon 14, clone 14, Upstate®, from mouse,
Reaktywność gatunkowa
canine, chicken, human, mouse, rat
Zastosowanie
immunocytochemistry
western blot
Anty-fosfo-Lamina A/C (Ser390), from rabbit,
Reaktywność gatunkowa
human
Zastosowanie
inhibition assay
western blot

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human LMNA,
Gatunek
human
MISSION® esiRNA, targeting mouse Lmna,
Gatunek
mouse