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NOTCH3

notch 3

Synonimy:
CADASIL, CASIL, IMF2
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(4854) Summary: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
  • Mouse(18131) notch 3
  • Rat(56761) notch 3
  • domestic guinea pig(100716867) notch 3
  • naked mole-rat(101722220) notch 3
  • Zebrafish(58066) notch homolog 3
  • dog(610439) notch 3
  • domestic cat(101088469) notch 3
  • sheep(101123554) notch 3
  • cow(789485) notch 3

Custom & Knockdown Gene Products

ELISA

Numer produktu
Opis
Gatunek
Human Notch-3 ELISA, for serum, plasma and cell culture supernatants,
Gatunek
human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Przeciwciało anty-Notch3 wytwarzane u królików, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-Notch 3 Antibody, clone 1G17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-NOTCH 3/N3ECD Antibody, clone 1E4, clone 1E4, 1 mg/mL, from mouse,
Reaktywność gatunkowa
human
Zastosowanie
electron microscopy
immunocytochemistry

western blot
Anti-NOTCH3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Monoclonal Anti-NOTCH3 antibody produced in mouse, clone 2E2, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
immunofluorescence

western blot

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
DAPT, ≥98% (HPLC), solid,
Gatunek
mouse, human, rat
L-685,458, >96% (HPLC), solid,
Gatunek
mouse, human, rat

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human NOTCH3,
Gatunek
human
MISSION® esiRNA, targeting mouse Notch3,
Gatunek
mouse