PLCE1
phospholipase C, epsilon 1
Synonimy:
NPHS3, PLCE, PPLC
Gatunek:
Human PLCE1 (51196), Mouse Plce1 (74055), Rat Plce1 (114633), domestic guinea pig Plce1 (100721203), naked mole-rat Plce1 (101706315), sheep PLCE1 (101105703), Domestic Rabbit PLCE1 (100344504), dog PLCE1 (486808), domestic cat PLCE1 (101088695), Horse PLCE1 (100061676) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(51196) Summary: This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
- Mouse(74055) phospholipase C, epsilon 1
- Rat(114633) phospholipase C, epsilon 1
- domestic guinea pig(100721203) phospholipase C, epsilon 1
- naked mole-rat(101706315) phospholipase C, epsilon 1
- sheep(101105703) phospholipase C, epsilon 1
- Domestic Rabbit(100344504) phospholipase C, epsilon 1
- dog(486808) phospholipase C, epsilon 1
- domestic cat(101088695) phospholipase C, epsilon 1
- Horse(100061676) phospholipase C, epsilon 1
- cow(519037) phospholipase C, epsilon 1
- Zebrafish(568288) phospholipase C, epsilon 1
- chicken(428962) phospholipase C, epsilon 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-PLCE1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry