PTEN
phosphatase and tensin homolog
Synonimy:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Gatunek:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), naked mole-rat Pten (101714930), domestic guinea pig Pten (100723659), sheep PTEN (101119351), cow PTEN (540786), domestic cat PTEN (101091813), dog PTEN (403832)
Identyfikator UniProtKB:
Identyfikator genu:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- naked mole-rat(101714930) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-PTEN antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
canine, human, mouse, rat
Zastosowanie
ELISA
western blot
western blot
Przeciwciało anty-PTENwytwarzane u królika, ,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunofluorescence
western blot
western blot
Przeciwciało anty-fosfo-PTEN-S370wytwarzane u królika, ,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
western blot
Anti-PTEN Antibody, clone A2b1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
bovine, canine, feline, human, monkey, mouse, porcine, rat
Zastosowanie
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN Antibody, clone 6H2.1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot