UBE3A
ubiquitin protein ligase E3A
Synonimy:
ANCR, AS, E6-AP, EPVE6AP, HPVE6A
Gatunek:
Human UBE3A (7337), Mouse Ube3a (22215), Rat Ube3a (361585), naked mole-rat Ube3a (101709173), Domestic Rabbit UBE3A (100342825), sheep UBE3A (101114391), domestic guinea pig Ube3a (100730511), dog UBE3A (479010), domestic cat UBE3A (101089941), cow UBE3A (533136) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(7337) Summary: This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(22215) ubiquitin protein ligase E3A
- Rat(361585) ubiquitin protein ligase E3A
- naked mole-rat(101709173) ubiquitin protein ligase E3A
- Domestic Rabbit(100342825) ubiquitin protein ligase E3A
- sheep(101114391) ubiquitin protein ligase E3A
- domestic guinea pig(100730511) ubiquitin protein ligase E3A
- dog(479010) ubiquitin protein ligase E3A
- domestic cat(101089941) ubiquitin protein ligase E3A
- cow(533136) ubiquitin protein ligase E3A
- Horse(100050725) ubiquitin protein ligase E3A
- Zebrafish(792398) ubiquitin protein ligase E3A
- fruit fly(39266) Ubiquitin protein ligase E3A
- chicken(418686) ubiquitin protein ligase E3A
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Monoclonal Anti-UBE3A antibody produced in mouse, clone 2F6, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-UBE3A antibody produced in mouse, clone 3E5, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
western blot
western blot
Przeciwciało anty-E6AP, serum, from rabbit,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunoprecipitation (IP)
western blot
western blot
Anti-UBE3A (ab1) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Zastosowanie
western blot
Przeciwciało anty-UBE3A, klon 10H7.1, clone 10H7.1, from mouse,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
esiRNA
Numer produktu
Opis
Gatunek