Wszystkie zdjęcia(1)

16033

Sigma-Aldrich

1,2-Propanediol

meets analytical specification of Ph. Eur., BP, USP, ≥99.5%

Synonim(y):
1,2-PDO, Propylene glycol
Wzór liniowy:
CH3CH(OH)CH2OH
Numer CAS:
Masa cząsteczkowa:
76.09
Beilstein:
1340498
Numer EC:
Numer MDL:
Identyfikator substancji w PubChem:
NACRES:
NA.21

gęstość pary

2.62 (vs air)

Poziom jakości

200

ciśnienie pary

0.08 mmHg ( 20 °C)

próba

≥99.5%

forma

liquid

temp. samozapłonu

779 °F

jakość

meets analytical specification of Ph. Eur., BP, USP

okres trwałości

24 mo.

granice wybuchowości

12.5 %

zanieczyszczenia

acidic reac. impurities, complies
organic volatile impurities, complies (GC)
oxidizing substances, complies
reducing matter, complies
residual solvents, complies
≤0.0005% heavy metals (as Pb)
≤0.002% free alkali (as NaOH)
≤0.003% free acid (as CH3COOH)
≤0.2% water (Karl Fischer)

pozostałość po prażeniu

≤0.005% (as SO4)

współczynnik refrakcji

n20/D 1.431-1.433
n20/D 1.432 (lit.)

tw

187 °C (lit.)

mp

−60 °C (lit.)

gęstość

1.036 g/mL at 25 °C (lit.)

ślady anionów

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

przydatność

complies for appearance of solution

SMILES string

CC(O)CO

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

InChI key

DNIAPMSPPWPWGF-UHFFFAOYSA-N

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Opis ogólny

1,2-Propanediol is an important petrochemical that can be prepared by the hydrogenolysis of glycerol. It is mainly used as a cryoprotectant for biological samples and also as an additive in food, cosmetic and pharmaceutical industries.
1,2-Propanediol is an 1,2-alkanediol. It can be obtained from glycerol, via hydrogenolysis in the presence of Ru/C and Amberlyst ion-exchange resins.

Zastosowanie

1,2-Propanediol may be employed as a cryoprotective agent for the preservation (by cooling to sub-zero temperatures) of human embryos and and oocytes (human and mouse).

Opakowanie

bottled under inert gas

Inne uwagi

The article number 16033-4X5L will be discontinued. Please order the single bottle 16033-5L which is physically identical with the same exact specifications.
The article number 16033-6X1L will be discontinued. Please order the single bottle 16033-1L which is physically identical with the same exact specifications.
The article number 16303-4X2.5L-R will be discontinued. Please order the single bottle 16303-2.5L-R which is physically identical with the same exact specifications.

Kod klasy składowania

10 - Combustible liquids

WGK

WGK 1

Temperatura zapłonu °F

219.2 °F - closed cup

Temperatura zapłonu °C

104 °C - closed cup

Środki ochrony indywidualnej

Eyeshields, Gloves

Certyfikat analizy

Świadectwo pochodzenia

Aqueous phase hydrogenolysis of glycerol to 1, 2-propanediol without external hydrogen addition.
Roy D, et al.
Catalysis Today, 156(1), 31-37 (2010)
D A Gook et al.
Human reproduction (Oxford, England), 8(7), 1101-1109 (1993-07-01)
Human and mouse oocytes were cryopreserved by a slow freeze, rapid thaw method, using propanediol (PROH) as the cryoprotectant. A simulated cryopreservation was also included in the study to detect the level of damage attributable to the PROH alone. Comparison
Glycerol hydrogenolysis to 1, 2-propanediol catalyzed by a heat-resistant ion-exchange resin combined with Ru/C.
Miyazawa T, et al.
Applied Catalysis A: General, 329, 30-35 (2007)
B Lassalle et al.
Fertility and sterility, 44(5), 645-651 (1985-11-01)
Eighty-five human embryos fertilized in vitro were frozen and thawed with 1,2 propanediol as a cryoprotective agent. The effects of viability of in vitro culture duration, stage, and morphologic appearance of embryos were examined after thawing. Survival was higher for
Yusha Imtiaz et al.
Nanomaterials (Basel, Switzerland), 10(8) (2020-08-23)
Polysaccharides have been shown to have immunomodulatory properties. Modulation of the immune system plays a crucial role in physiological processes as well as in the treatment and/or prevention of autoimmune and infectious diseases. Cellulose nanocrystals (CNCs) are derived from cellulose

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