C2210000

Cisplatin

European Pharmacopoeia (EP) Reference Standard

• Synonym(s): cis-Diammineplatinum(II) dichloride, cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin
• Linear Formula: Pt(NH₃)₂Cl₂
• CAS Number: 15663-27-1
• Molecular Weight: 300.05
• Numer EC: 239-733-8
• Numer MDL: MFCD00011623
• Identyfikator substancji w PubChem: 329774978
• NACRES: NA.24

Properties

• klasa czystości: pharmaceutical primary standard
• manufacturer/tradename: EDQM
• mp: 270 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: N.N.Cl[Pt]Cl
• InChI: 1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
• InChI key: LXZZYRPGZAFOLE-UHFFFAOYSA-L

Description

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for the preparation of the below-given solutions as per European Pharmacopoeia:

• Reference solutions in the identification using infrared absorption spectroscopy and thin-layer chromatography, testing of related substances, and assay using liquid chromatography (General text 2.2.29) of cisplatin, according to the monograph 0599
• Reference solution (b) for the testing of related substances in carboplatin using liquid chromatography (General text 2.2.29), according to the monograph 1081

Opakowanie

1 ea

100 mg

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Działania biochem./fizjol.

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Przestroga

Please find SDS provided by EDQM here..

Inne uwagi

Sales restrictions may apply.

Safety Information

• piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300 - H315 - H317 - H319 - H334 - H335 - H350
• Zwroty wskazujące środki ostrożności: P201 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable