M2305000

Mitoxantrone hydrochloride

European Pharmacopoeia (EP) Reference Standard

• Synonym(s): Mitoxantrone dihydrochloride, 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
• Empirical Formula (Hill Notation): C₂₂H₂₈N₄O₆ · 2HCl
• CAS Number: 70476-82-3
• Molecular Weight: 517.40
• Numer MDL: MFCD00242943
• Identyfikator substancji w PubChem: 329817936
• NACRES: NA.24

Properties

• klasa czystości: pharmaceutical primary standard
• manufacturer/tradename: EDQM
• application(s): pharmaceutical (small molecule)
• format: neat
• temp. przechowywania: 2-8°C
• SMILES string: Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
• InChI: 1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
• InChI key: ZAHQPTJLOCWVPG-UHFFFAOYSA-N
• Gene Information: human ... TOP2A(7153)

Description

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Działania biochem./fizjol.

Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.

Opakowanie

Unit quantity: 60 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Przestroga

Please find SDS provided by EDQM here..

Inne uwagi

Sales restrictions may apply.

Safety Information

• piktogramy: GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H340 - H360
• Zwroty wskazujące środki ostrożności: P201 - P308 + P313
• Klasyfikacja zagrożeń: Muta. 1B - Repr. 1B
• Kod klasy składowania: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable