Produkty
Produkty
Wszystkie zdjęcia(1)
M4627
1-Methylnicotinamide chloride
analytical standard
Synonim(y):
N-Methylnicotinic acid amide chloride
Wzór liniowy:
C7H9N2OCl
Numer CAS:
Masa cząsteczkowa:
172.61
Numer MDL:
Identyfikator substancji w PubChem:
NACRES:
NA.24
klasa czystości
analytical standard
Poziom jakości
100
próba
≥97.5%
forma
powder
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
kolor
white
application(s)
forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products
format
neat
SMILES string
[Cl-].C[n+]1cccc(c1)C(N)=O
InChI
1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
InChI key
BWVDQVQUNNBTLK-UHFFFAOYSA-N
Powiązane kategorie
Opis ogólny
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.
Zastosowanie
1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Opakowanie
1 g in poly bottle
Działania biochem./fizjol.
Urinary excretion product of niacin metabolism
Kod klasy składowania
13 - Non Combustible Solids
WGK
WGK 3
Temperatura zapłonu °F
Not applicable
Temperatura zapłonu °C
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikat analizy
Wprowadź numer partii, aby wyszukać certyfikat analizy (COA).
Świadectwo pochodzenia
Wprowadź numer partii, aby wyszukać świadectwo pochodzenia (COO).
Więcej dokumentów
Ceny i zamawianie
Robert Nowak et al.
European journal of pharmacology, 640(1-3), 102-111 (2010-05-08)
The aim of the study was to examine the effect of 1-methylnicotinamide (MNA) and 1-methyl-3-nitropyridine (MNP) on mitochondria activity and proliferation of endothelial EA.hy926 cells. The activity of MNA was also referred to nicotinamide (NAM) being MNA metabolic precursor. NAM
M N Khodosovskiĭ et al.
Eksperimental'naia i klinicheskaia farmakologiia, 73(4), 11-13 (2010-05-22)
We have studied the effect of 1-methylnicotinamide (MNA) on prooxidant - antioxidant balance parameters by measuring the concentrations of lipid peroxidation products (conjugated dienes (CD) and Schiff bases (SB)) and antioxidant system factors (alpha-tocoferol (alpha-T), retinol (Ret) in the blood
Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 27(5), 543-547 (2012-03-29)
Aldehyde oxidase (AO) plays a role in metabolizing many drugs, such as methotrexate and 6-mercaptopurine. We previously showed that AO activity in rat liver rapidly increases from birth, reaching a plateau within 4 weeks, and is regulated at the protein
Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status
Creeke IP, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817, 247-253 (2005)
Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 26(1), 94-101 (2010-11-19)
Aldehyde oxidase (AO) plays an important role in metabolizing antitumor and antiviral drugs, including methotrexate, cyclophosphamide and acyclovir. Green tea and its catechins have been shown to modulate the activities of various xenobiotic-metabolizing cytochrome P450 species, both in vivo and
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