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M4627

Supelco

1-Methylnicotinamide chloride

analytical standard

Synonim(y):
N-Methylnicotinic acid amide chloride
Wzór liniowy:
C7H9N2OCl
Numer CAS:
Masa cząsteczkowa:
172.61
Numer MDL:
Identyfikator substancji w PubChem:
NACRES:
NA.24

klasa czystości

analytical standard

Poziom jakości

100

próba

≥97.5%

forma

powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

kolor

white

application(s)

forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products

format

neat

SMILES string

[Cl-].C[n+]1cccc(c1)C(N)=O

InChI

1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H

InChI key

BWVDQVQUNNBTLK-UHFFFAOYSA-N

Opis ogólny

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Zastosowanie

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Opakowanie

1 g in poly bottle

Działania biochem./fizjol.

Urinary excretion product of niacin metabolism

Kod klasy składowania

13 - Non Combustible Solids

WGK

WGK 3

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikat analizy

Wprowadź numer partii, aby wyszukać certyfikat analizy (COA).

Świadectwo pochodzenia

Wprowadź numer partii, aby wyszukać świadectwo pochodzenia (COO).

Więcej dokumentów

Ceny i zamawianie

Robert Nowak et al.
European journal of pharmacology, 640(1-3), 102-111 (2010-05-08)
The aim of the study was to examine the effect of 1-methylnicotinamide (MNA) and 1-methyl-3-nitropyridine (MNP) on mitochondria activity and proliferation of endothelial EA.hy926 cells. The activity of MNA was also referred to nicotinamide (NAM) being MNA metabolic precursor. NAM
M N Khodosovskiĭ et al.
Eksperimental'naia i klinicheskaia farmakologiia, 73(4), 11-13 (2010-05-22)
We have studied the effect of 1-methylnicotinamide (MNA) on prooxidant - antioxidant balance parameters by measuring the concentrations of lipid peroxidation products (conjugated dienes (CD) and Schiff bases (SB)) and antioxidant system factors (alpha-tocoferol (alpha-T), retinol (Ret) in the blood
Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 27(5), 543-547 (2012-03-29)
Aldehyde oxidase (AO) plays a role in metabolizing many drugs, such as methotrexate and 6-mercaptopurine. We previously showed that AO activity in rat liver rapidly increases from birth, reaching a plateau within 4 weeks, and is regulated at the protein
Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status
Creeke IP, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817, 247-253 (2005)
Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 26(1), 94-101 (2010-11-19)
Aldehyde oxidase (AO) plays an important role in metabolizing antitumor and antiviral drugs, including methotrexate, cyclophosphamide and acyclovir. Green tea and its catechins have been shown to modulate the activities of various xenobiotic-metabolizing cytochrome P450 species, both in vivo and

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