PHR1224

Supelco

Aminocaproic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonim(y):
ε-Aminocaproic acid, EACA, 6-Aminocaproic acid, 6-Aminohexanoic acid
Wzór liniowy:
H2N(CH2)5CO2H
Numer CAS:
Masa cząsteczkowa:
131.17
Beilstein/REAXYS Number:
906872
Numer EC:
Numer MDL:
Identyfikator substancji w PubChem:
NACRES:
NA.24

Poziom jakości

300

klasa czystości

certified reference material
pharmaceutical secondary standard

formularz

neat

Certyfikat analizy

current certificate can be downloaded

zastosowania

HPLC: suitable
gas chromatography (GC): suitable

mp

207-209 °C (dec.) (lit.)

Wyróżniony przemysł

Pharmaceutical (small molecule)

format

neat

identyfikowalność wg farmakopei

traceable to PhEur A0420000
traceable to USP 1021000

SMILES string

NCCCCCC(O)=O

InChI

1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

InChI key

SLXKOJJOQWFEFD-UHFFFAOYSA-N

Gene Information

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Opis ogólny

Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Zastosowanie

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Aminocaproic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry and in bulk and injectable forms using colorimetric method.

Działania biochem./fizjol.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAA9036 in the slot below. This is an example certificate only and may not be the lot that you receive.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 2

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

Certyfikat analizy

Świadectwo pochodzenia

Development of Colorimetric Method for the Analysis of Aminocaproic Acid Using DCQ
Shantier SW, et al.
World Journal of Pharmaceutical Research, 4(4), 234-240 (2015)
Fluorimetric determination of aminocaproic acid in pharmaceutical formulations using a sequential injection analysis system
Pinto PCAG, et al.
Talanta, 68(3), 857-862 (2006)
Aminocaproic acid: use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia
Gardner FH and Helmer RE
JAMA : The Journal of the American Medical Association, 243(1), 35-37 (1980)
The absorption, distribution, and excretion of ?-aminocaproic acid following oral or intravenous administration to man
McNicol GP, et al.
The Journal of Laboratory and Clinical Medicine, 59(1), 15-24 (1962)
Ed M Choi et al.
Laboratory investigation; a journal of technical methods and pathology, 89(6), 624-635 (2009-05-13)
Recent cases of prion transmission in humans following transfusions using blood donated by patients with asymptomatic variant Creutzfeldt-Jakob disease (CJD) implicate the presence of prion infectivity in peripheral blood. In this study, we examined the levels of the normal, cellular...

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