PHR1487

Kanamycin Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Kanamycin sulfate from Streptomyces kanamyceticus, Kanamycin A, Kanamycin sulfate salt
• Empirical Formula (Hill Notation): C₁₈H₃₆N₄O₁₁ · H₂O₄S
• CAS Number: 25389-94-0
• Molecular Weight: 582.58
• Numer EC: 246-933-9
• Numer MDL: MFCD00070253
• Identyfikator substancji w PubChem: 329823411
• NACRES: NA.24

Properties

• klasa czystości: certified reference material; pharmaceutical secondary standard
• Poziom jakości: 300
• Agency: traceable to BP 861; traceable to Ph. Eur. K0200000; traceable to USP 1355006
• Certyfikat analizy: current certificate can be downloaded
• opakowanie: pkg of 500 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• temp. przechowywania: 2-8°C
• SMILES string: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
• InChI key: OOYGSFOGFJDDHP-KMCOLRRFSA-N

Description

Opis ogólny

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Kanamycin Sulfate, generated by specific strains of Streptomyces kanamyceticus, belongs to the class of aminoglycoside antibiotics. It is known to act effectively against a broad spectrum of Gram-negative and Gram-positive bacteria.

Zastosowanie

Kanamycin Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Opakowanie

500 mg

Działania biochem./fizjol.

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.

Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.

Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAB7808 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• piktogramy: GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H360D
• Zwroty wskazujące środki ostrożności: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Klasyfikacja zagrożeń: Repr. 1B
• Kod klasy składowania: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable