PHR1787

Cytarabine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Cytosine β-D-arabinofuranoside, (β-D-Arabinofuranosyl)cytosine, Ara-C, Arabinocytidine, Arabinosylcytosine, Cytarabine, Cytosine arabinoside
• Empirical Formula (Hill Notation): C₉H₁₃N₃O₅
• CAS Number: 147-94-4
• Molecular Weight: 243.22
• Beilstein: 89175
• Numer EC: 205-705-9
• Numer MDL: MFCD00066487
• Identyfikator substancji w PubChem: 329823613
• NACRES: NA.24

Properties

• klasa czystości: certified reference material; pharmaceutical secondary standard
• Poziom jakości: 300
• Agency: traceable to BP 383; traceable to Ph. Eur. C3350000; traceable to USP 1162002
• Certyfikat analizy: current certificate can be downloaded
• opakowanie: pkg of 500 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• temp. przechowywania: 2-8°C
• SMILES string: NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
• InChI: 1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
• InChI key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
• Gene Information: human ... POLA1(5422) , POLA2(23649) , POLD1(5424) , POLD2(5425) , POLD3(10714) , POLD4(57804) , POLE(5426) , POLE2(5427) , POLE3(54107) , PRIM1(5557) , PRIM2(5558)

Description

Opis ogólny

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Opakowanie

500 mg

Działania biochem./fizjol.

Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAB3688 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• piktogramy: GHS07,GHS08
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H317 - H361fd
• Zwroty wskazujące środki ostrożności: P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313
• Klasyfikacja zagrożeń: Repr. 2 - Skin Sens. 1
• Kod klasy składowania: 11 - Combustible Solids
• WGK: WGK 3