PHR1789

Doxorubicin Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Doxorubicin hydrochloride, DOX, Hydroxydaunorubicin hydrochloride
• Empirical Formula (Hill Notation): C₂₇H₂₉NO₁₁ · HCl
• CAS Number: 25316-40-9
• Molecular Weight: 579.98
• Beilstein: 4229251
• Numer EC: 246-818-3
• Numer MDL: MFCD00077757
• Identyfikator substancji w PubChem: 329823614

Properties

• klasa czystości: certified reference material; pharmaceutical secondary standard
• Poziom jakości: 300
• Agency: traceable to BP 990; traceable to Ph. Eur. D2975000; traceable to USP 1225703
• forma: powder
• Certyfikat analizy: current certificate can be downloaded
• opakowanie: pkg of 200 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 216 °C (dec.) (lit.)
• application(s): pharmaceutical (small molecule)
• temp. przechowywania: -10 to -25°C
• SMILES string: Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
• InChI key: MWWSFMDVAYGXBV-RUELKSSGSA-N
• Gene Information: human ... TOP2A(7153)

Description

Opis ogólny

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.

Zastosowanie

This pharmaceutical secondary standard can also be used as follows:

• Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples[1]
• Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe₂O₄) modified carbon paste electrode in biological fluid and injection samples[2]
• Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
• RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations[3]
• Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples[4]

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• piktogramy: GHS07,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302 - H340 - H350 - H360FD
• Zwroty wskazujące środki ostrożności: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Kod klasy składowania: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable