Merck
All Photos(1)

PHR1789

Supelco

Doxorubicin Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Doxorubicin hydrochloride, DOX, Hydroxydaunorubicin hydrochloride
Empirical Formula (Hill Notation):
C27H29NO11 · HCl
CAS Number:
Molecular Weight:
579.98
Beilstein:
4229251
Numer EC:
Numer MDL:
Identyfikator substancji w PubChem:

klasa czystości

certified reference material
pharmaceutical secondary standard

Poziom jakości

300

Agency

traceable to BP 990
traceable to Ph. Eur. D2975000
traceable to USP 1225703

forma

powder

Certyfikat analizy

current certificate can be downloaded

opakowanie

pkg of 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

216 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

temp. przechowywania

-10 to -25°C

SMILES string

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI key

MWWSFMDVAYGXBV-RUELKSSGSA-N

Gene Information

human ... TOP2A(7153)

Looking for similar products? Visit Product Comparison Guide

Opis ogólny

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.

Zastosowanie

This pharmaceutical secondary standard can also be used as follows:
  • Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples[1]
  • Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe2O4) modified carbon paste electrode in biological fluid and injection samples[2]
  • Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
  • RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations[3]
  • Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples[4]

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

piktogramy

Exclamation markHealth hazard

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Zwroty wskazujące środki ostrożności

Klasyfikacja zagrożeń

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

Kod klasy składowania

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service