PHR2091

Nicotinamide Impurity F

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonim(y): N1-Methylnicotinamide chloride, N-Methylnicotinic acid amide chloride, 1-Methylnicotinamide chloride, MNA, 3-Carbamyl-1-methylpyridinium chloride
• Empirical Formula (Hill Notation): C₇H₉ClN₂O
• Numer CAS: 1005-24-9
• Masa cząsteczkowa: 172.61

Właściwości

• klasa czystości: certified reference material; pharmaceutical secondary standard
• forma: powder
• opakowanie: pkg of 100 mg
• temp. przechowywania: 2-30°C
• InChI: 1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
• InChI key: BWVDQVQUNNBTLK-UHFFFAOYSA-N

Opis

Opis ogólny

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Działania biochem./fizjol.

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAB9787 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 13 - Non Combustible Solids
• WGK: WGK 3
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable