C2538

Carboplatin

• Synonym(s): cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
• Linear Formula: [C₄H₆(CO₂)₂]Pt(NH₃)₂
• CAS Number: 41575-94-4
• Molecular Weight: 371.25
• Numer EC: 255-446-0
• Numer MDL: MFCD00070464
• Identyfikator substancji w PubChem: 24278303
• NACRES: NA.77

Properties

• forma: powder
• Poziom jakości: 100
• spektrum działania antybiotyku: neoplastics
• inicjator: Bristol-Myers Squibb
• SMILES string: N.N.O=C1O[Pt]OC(=O)C12CCC2
• InChI: 1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2
• InChI key: OLESAACUTLOWQZ-UHFFFAOYSA-L

Description

Opis ogólny

Carboplatin is used to treat testicular, ovarian and breast cancer.

Zastosowanie

Carboplatin has been used:

• in chemotherapy-induced thrombocytopenia mouse model and treatment
• to induce cell death in a large subset of colorectal cancer cells
• in the evaluation of cell proliferation and chemosensitivity
• as a positive control for suppressed cell growth

Opakowanie

10, 25, 100, 250 mg in glass bottle

Działania biochem./fizjol.

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

Cechy i korzyści

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• piktogramy: GHS07,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302 + H312 + H332 - H317 - H334 - H340 - H360
• Zwroty wskazujące środki ostrożności: P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P308 + P313
• Klasyfikacja zagrożeń: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1
• Kod klasy składowania: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges