OSBPL8 (oxysterol binding protein-like 8), also called as OSBP-related protein 8 (ORP8) is localized to the endoplasmic reticulum (ER) and binds to 25-hydroxycholesterol. It is predominantly expressed in macrophages, liver, spleen, kidney, and brain.
Oxysterol-binding protein-related protein 8 recombinant protein epitope signature tag (PrEST)
OSBPL8 (oxysterol binding protein-like 8) gene encodes a protein belonging to the oxysterol-binding protein (OSBP) family. The members of this family contain a pleckstrin homology domain at the N-terminus and a highly conserved OSBP-type sterol-binding domain at the C-terminal region. The protein inhibits ATP binding cassette transporter A1 (ABCA1) expression and prevents macrophage cholesterol efflux, regulating the development of atherosclerosis.
Cechy i korzyści
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.