SLC6A15 (solute carrier family 6, member 15) gene is highly expressed in human brains, where it is especially expressed in hippocampus. Its expression is restricted to neurons. This gene is localized to human chromosome 12q21.31. The coded protein is a Na+-dependent branched amino acid transporter, which is a member of the SLC6 family of transporters.
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT73 recombinant protein epitope signature tag (PrEST)
SLC6A15 (solute carrier family 6, member 15) plays a role in major depression (MD), where its reduced expression is responsible for changed neuronal circuits. In unipolar depression, this protein is linked to cognitive abnormalities, and it also plays a role in the secretion of adrenocorticotropic hormone (ACTH) and cortisol.
Cechy i korzyści
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.