HPA011911

Sigma-Aldrich

Anti-DSC2 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonim(y):
Anti-Desmocollin-3, Anti-Desmocollin-2 precursor, Anti-Desmosomal glycoprotein II and III
Numer w atlasie ludzkich białek:

pochodzenie biologiczne

rabbit

Poziom jakości

100

forma przeciwciała

affinity isolated antibody

antibody product type

primary antibodies

klon

polyclonal

linia produktu

Prestige Antibodies® Powered by Atlas Antibodies

formularz

buffered aqueous glycerol solution

species reactivity

human

opakowanie

antibody small pack of 25 μL

rozszerzona walidacja

orthogonal RNAseq
independent
Learn more about Antibody Enhanced Validation

zastosowania

immunohistochemistry: 1:200- 1:500

sekwencja immunogenna

IGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNS

białko sprzężone

unconjugated

numer dostępu UniProt

wysyłka w ciągu

wet ice

temp. przechowywania

−20°C

Gene Information

human ... DSC2(1824)

Immunogen

Desmocollin-2 precursor recombinant protein epitope signature tag (PrEST)

Działania biochem./fizjol.

DSC2 (Desmocollin-2) is a transmembrane cadherin glycoprotein present in the desmosomal cell-cell adhesion structure. It is a member of the desmosomal cadherin family and is associated with tumor progression. It mainly performs in the cell-cell adhesion mechanism. Studies have been reported regarding the involvement of DSC2 in the regulation of cell invasiveness by controlling the cell-cell attachment and cytoskeleton rearrangement. Its expression has been found in several types of cancers such as colorectal, pancreatic, gastric, lung and urothelial cancer. Mutation in the DSC2 gene causes an inherited cardiac disease, arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) characterized by myocardial atrophy, fibro-fatty replacement, and a high risk of ventricular arrhythmias.

Cechy i korzyści

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Powiązanie

Corresponding Antigen APREST72495.

Postać fizyczna

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Informacje prawne

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Środki ochrony indywidualnej

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

null
Elisabetta Lazzarini et al.
Human mutation, 36(4), 403-410 (2015-02-14)
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease characterized by myocardial atrophy, fibro-fatty replacement, and a high risk of ventricular arrhythmias that lead to sudden death. In 2009, genetic data from 57 publications were collected in the arrhythmogenic right ventricular...

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