SAB4200067

Anti-PSPC1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-Paraspeckle protein 1, Anti-PSP1
• NACRES: NA.41

Properties

• pochodzenie biologiczne: rabbit
• Poziom jakości: 200
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• antibody product type: primary antibodies
• klon: polyclonal
• forma: buffered aqueous solution
• masa cząsteczkowa: antigen ~45 kDa; antigen ~59 kDa
• species reactivity: human
• stężenie: ~1.0 mg/mL
• technique(s): immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells; indirect immunofluorescence: 1.25-2.5 μg/mL using paraformaldehyde fixed HEK-293T cells; western blot: 0.5-1 μg/mL using lysates of HEK-293T cells
• numer dostępu UniProt: Q8WXF1
• transport: dry ice
• temp. przechowywania: −20°C
• Gene Information: human ... PSPC1(55269) ; mouse ... Pspc1(66645) ; rat ... Pspc1(305910)

Description

Opis ogólny

PSPC1 has two isoforms α and β.

Paraspeckle component 1 (PSPC1) is encoded by the gene mapped to human chromosome 13q12.11. The encoded protein is a member of DBHS (Drosophila Behavior Human Splicing) family of proteins.

Zastosowanie

Anti-PSPC1 (C-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• ribonucleoprotein immunoprecipitation assay
• immunofluorescence
• immunocytochemistry

Działania biochem./fizjol.

Paraspeckle component 1 (PSPC1) is involved in the regulation of nuclear receptors such as the progesterone receptor and the thyroid receptor and in a wide range of processes such as splicing and RNA metabolism.

Since paraspeckle component 1 (PSPC1) has lower background nucleoplasmic signal in various cell types compared to other members of DBHS (drosophila behavior human splicing) family of proteins, it is frequently used as a marker for paraspeckles. The encoded protein plays a vital role in regulation of transcription. Deletion of the gene is associated with the hindered psychomotor development, muscle hypotonia, unilateral microphtalmia with ptosis, congenital eye malformation and facial dysmorphic features.

Postać fizyczna

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Kod klasy składowania: 12 - Non Combustible Liquids
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable