Wszystkie zdjęcia(2)

SAB4501173

Sigma-Aldrich

Anti-Connexin 43 antibody produced in rabbit

affinity isolated antibody

Synonim(y):
Connexin 43, CXA1, CXN-43, CX43, Gap junction 43 kDa heart protein
Numer MDL:
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

100

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

antibody product type

primary antibodies

klon

polyclonal

forma

buffered aqueous solution

masa cząsteczkowa

antigen 43 kDa

species reactivity

human

stężenie

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

numer dostępu NCBI

numer dostępu UniProt

transport

wet ice

temp. przechowywania

−20°C

Gene Information

human ... GJA1(2697)

Opis ogólny

Connexin 43 (Cx43) is also known as GJA1 (gap junction protein α 1) and belongs to a large family of homologous connexin proteins. It has an intracellular N-terminus, four transmembrane domains, two extracellular loops, one cytoplasmic loop and an intracellular C-terminus. It is located on human chromosome 6q22-q23.
Anti-Connexin 43 Antibody detects endogenous levels of total Connexin 43 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Connexin 43.

Immunogen Range: 226-275

Zastosowanie

Anti-Connexin 43 antibody has been used in immunohistochemistry.

Działania biochem./fizjol.

Mutations in Connexin 43 (Cx43) gene result in pleiotropic phenotype of oculodentodigital dysplasia. Connexin 43 participates in the multiplication and differentiation of mature T cells. It also participates in the secretion and manufacturing of cytokines. It helps to release lactate from glycolytic pancreatic ductal adenocarcinoma cells.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Postać fizyczna

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Kod klasy składowania

12 - Non Combustible Liquids

WGK

nwg

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

Certyfikat analizy

Świadectwo pochodzenia

Timothy Bage et al.
Archives of dermatological research, 311(8), 647-652 (2019-06-07)
In this study, we characterised the effect that seeding keratinocytes on the papillary and reticular dermis had on the extracellular matrix and tissue integrity ex vivo. Human skin explants from consented patients (n = 6) undergoing routine surgery were cultured at a
Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning
Vedantham V, et al.
Developmental Biology, 373, 149-162 (2013)
Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension
Ni X, et al.
PLoS ONE, 12 (2017)
Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia
Paznekas WA, et al.
American Journal of Human Genetics, 72, 408-418 (2003)
Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells
Dovmark TH, et al.
Oncogene, 36, 4538-4550 (2017)

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej