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Sushma Singh et al.
Rheumatology international, 34(10), 1395-1400 (2014-04-11)
MicroRNAs (miRNAs) are non-coding RNA that modulate the expression of multiple target genes at the post-transcriptional level. Single-nucleotide polymorphisms (SNPs) in pre-miRNAs can alter miRNA expression, and polymorphism in target molecules can affect binding to target mRNA. Studies have shown
Jeffrey R Bishop et al.
Psychopharmacology, 232(1), 145-154 (2014-08-07)
Type-3 metabotropic glutamate receptor gene (GRM3) single nucleotide polymorphisms (SNPs) have been associated with cognitive performance and prefrontal cortex brain activity in chronically treated schizophrenia patients. Whether these SNPs are associated with cognitive and symptom response to antipsychotic therapy has
Ana Beatriz DePaula-Silva et al.
Virology, 477, 10-17 (2015-01-27)
Vpr and Vpx are a group of highly related accessory proteins from primate lentiviruses. Despite the high degree of amino acid homology within this group, these proteins can be highly divergent in their functions. In this work, we constructed chimeric
Jonathan M Locke et al.
Diabetologia, 58(4), 745-748 (2015-01-31)
Intronic single nucleotide polymorphisms (SNPs) in the CDKAL1 gene are associated with risk of developing type 2 diabetes. A strong correlation between risk alleles and lower levels of the non-coding RNA, CDKAL1-v1, has recently been reported in whole blood extracted
Yugeesh R Lankadeva et al.
Circulation, 131(3), 280-288 (2014-11-06)
Children born with reduced congenital renal mass have an increased risk of hypertension and chronic kidney disease in adulthood, although the mechanisms are poorly understood. Similar sequelae occur after fetal uninephrectomy (uni-x) in sheep, leading to a 30% nephron deficit.
Mai Akada et al.
Cellular signalling, 26(12), 2879-2884 (2014-09-23)
Anoikis is a specific type of apoptosis induced by detachment of epithelial cells from extracellular matrix, and acquiring resistance to anoikis is an important step that enables cancer cells to metastasize. EphA2, which is overexpressed in a variety of human
Hui-Ying Liu et al.
World journal of gastroenterology, 21(10), 2918-2925 (2015-03-18)
To improve an asialoglycoprotein receptor (ASGPR)-based enrichment method for detection of circulating tumor cells (CTCs) of hepatocellular carcinoma (HCC). Peripheral blood samples were collected from healthy subjects, patients with HCC or various other cancers, and patients with hepatic lesions or
Maryam Monajemzadeh et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(9), 734-741 (2013-12-11)
Neuroblastoma is the most common extracranial solid tumor of children, accounting for an estimated 15% cancer-related deaths in this period. It has been hypothesized that drug resistance of cancer stem cells may be responsible for chemotherapy failure, sustained tumor growth
Mohannad Nassar et al.
Journal of endodontics, 41(2), 242-247 (2014-12-03)
The objectives of this study were to investigate the effect of phytic acid, inositol hexakisphosphate (IP6), as a final rinse on the surface of instrumented root canals and smear-layered flat dentin surfaces treated with sodium hypochlorite (NaOCl) and to evaluate
Yingchi Zhang et al.
PloS one, 9(8), e103970-e103970 (2014-08-02)
The development of early B cells, which are generated from hematopoietic stem cells (HSCs) in a series of well-characterized stages in bone marrow (BM), represents a paradigm for terminal differentiation processes. Akt is primarily regulated by phosphorylation at Thr308 by
Angelica Guerrero-Castilla et al.
Environmental toxicology and pharmacology, 38(3), 742-750 (2014-10-13)
Exposure to coal dust has been associated with different chronic diseases and mortality risk. This airborne pollutant is produced during coal mining and transport activities, generating environmental and human toxicity. The aim of this study was to determine the effects
Kara Lea Vine et al.
Pharmaceutical research, 32(3), 1045-1054 (2014-09-19)
Overexpression of the serine protease urokinase (uPA) is recognised as an important biomarker of metastatic disease and a druggable anticancer target. Plasminogen activator inhibitor type-2 (PAI-2/SerpinB2) is a specific uPA inhibitor with proven potential for use in targeted therapy. However
María J Alvarez-López et al.
Journal of neuroinflammation, 11, 126-126 (2014-07-24)
Aging is characterized by a low-grade systemic inflammation that contributes to the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). However, little knowledge is currently available on the molecular processes leading to chronic neuroinflammation. In this context, recent studies
Wilfredo F Garcia-Beltran et al.
Cell, 184(2), 476-488 (2021-01-08)
Coronavirus disease 2019 (COVID-19) exhibits variable symptom severity ranging from asymptomatic to life-threatening, yet the relationship between severity and the humoral immune response is poorly understood. We examined antibody responses in 113 COVID-19 patients and found that severe cases resulting
Joshua O Sestak et al.
The AAPS journal, 16(6), 1185-1193 (2014-09-07)
Presentation of antigen with immune stimulating "signal" has been a cornerstone of vaccine design for decades. Here, the antigen plus immune "signal" of vaccines is modified to produce antigen-specific immunotherapies (antigen-SITs) that can potentially reprogram the immune response toward tolerance
Karen Müller Smith et al.
PloS one, 9(8), e103696-e103696 (2014-08-15)
Fibroblast growth factors (Fgfs) and their receptors (Fgfr) are expressed in the developing and adult CNS. Previous studies demonstrated a decrease in cortical interneurons and locomotor hyperactivity in mice with a conditional Fgfr1 deletion generated in radial glial cells during
Mi-Ran Cho et al.
Journal of clinical biochemistry and nutrition, 56(1), 49-56 (2015-02-14)
DNA damages and antioxidant status was assessed after 8 weeks of purple grape juice supplementation in male smokers depending on the glutathione S-transferase polymorphisms. Ninety-five smokers consumed 480 ml of purple grape juice for 8 weeks. The blood samples were collected
Micah Zuhl et al.
Cell stress & chaperones, 20(1), 85-93 (2014-07-27)
Chronic glutamine supplementation reduces exercise-induced intestinal permeability and inhibits the NF-κB pro-inflammatory pathway in human peripheral blood mononuclear cells. These effects were correlated with activation of HSP70. The purpose of this paper is to test if an acute dose of
Zhuoyang Fan et al.
PloS one, 10(4), e0120129-e0120129 (2015-04-02)
Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)-a significant problem in the administration of PTX to cancer patients. To increase the
Rossella Melchiotti et al.
BMC medical genetics, 15, 73-73 (2014-06-28)
Extracellular ATP is a pro-inflammatory molecule released by damaged cells. Regulatory T cells (Treg) can suppress inflammation by hydrolysing this molecule via ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), also termed as CD39. Multiple studies have reported differences in CD39+ Treg percentages
Sheng-Yi Chen et al.
Biochimica et biophysica acta, 1853(5), 929-939 (2015-02-18)
Cancer-associated fibroblasts play a crucial role in accelerating tumor progression, but there is a knowledge gap regarding the chemotactic signal activated in a tumor microenvironment. In this study, the expression of type IV collagen was knocked down using a lentiviral-mediated
Chek Meng Poh et al.
Infection and immunity, 82(11), 4854-4864 (2014-08-27)
CD8(+) T cells play a pathogenic role in the development of murine experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA) infection in C57BL/6 mice. Only a limited number of CD8(+) epitopes have been described. Here, we report the
Bettina M Jensen et al.
Journal of leukocyte biology, 95(6), 893-901 (2014-02-05)
Different protocols exist for in vitro development of HuMCs from hematopoietic stem cells, which results in distinct mast cells regarding molecular markers and activation patterns. Here, we introduce a SR profile using immunological, neurogenic, and pharmacological stimuli to characterize cellular
S Franzè et al.
International journal of pharmaceutics, 481(1-2), 79-83 (2015-02-07)
Low molecular weight heparins (LMWHs) are obtained from unfractionated heparin (UFH) through different depolymerization methods (DM), which produce compounds having specific chemical features and biological activity. It is then supposed that LMWHs also exhibit different skin permeability properties. The current
Vlastimil Tichý et al.
Biochemical and biophysical research communications, 433(4), 445-449 (2013-03-19)
Cysteine oxidation and covalent modification of redox sensitive transcription factors including p53 are known, among others, as important events in cell response to oxidative stress. All p53 family proteins p53, p63 and p73 act as stress-responsive transcription factors. Oxidation of
Azzah M Bannunah et al.
Molecular pharmaceutics, 11(12), 4363-4373 (2014-10-21)
This study investigated the effect of nanoparticle size (50 and 100 nm) and surface charge on their interaction with Caco-2 monolayers as a model of the intestinal epithelium, including cell internalization pathways and the level of transepithelial transport. Initially, toxicity
ZhaoHui Luo et al.
BMC medical genomics, 8, 13-13 (2015-04-19)
A novel class of transcripts, long non-coding RNAs (lncRNAs), has recently emerged as a key player in several biological processes, and important roles for these molecules have been reported in a number of complex human diseases, such as autoimmune diseases
Michael Wolf et al.
The International journal of oral & maxillofacial implants, 29(4), 976-983 (2014-07-18)
Maxillary sinus floor augmentation is a treatment that has been proposed for patients in whom the alveolar bone height is insufficient. This procedure is commonly used in patients aged 40 to 70 years and older. However, little information exists whether
Davi A G Mázala et al.
American journal of physiology. Cell physiology, 308(1), C33-C40 (2014-10-10)
Duchenne muscular dystrophy (DMD) is one of the most frequent types of muscular dystrophy. Alterations in intracellular calcium (Ca(2+)) handling are thought to contribute to the disease severity in DMD, possibly due to the activation of Ca(2+)-activated proteases. The purpose
Carla L Ellis et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(6), 875-886 (2013-12-07)
Xp11 translocation renal cell carcinomas harbor chromosome translocations involving the Xp11 breakpoint, resulting in gene fusions involving the TFE3 gene. The most common subtypes are the ASPSCR1-TFE3 renal cell carcinomas resulting from t(X;17)(p11;q25) translocation, and the PRCC-TFE3 renal cell carcinomas
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