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Wyświetlanie 1-30 of 1843 wyniki(-ów) na "216763" w ciągu Dokumenty
Wenwen Wang et al.
Toxicology and applied pharmacology, 313, 195-203 (2016-10-26)
Triptolide (TP), a diterpene triepoxide, is a major active component of Tripterygium wilfordii extracts, which are prepared as tablets and has been used clinically for the treatment of inflammation and autoimmune disorders. However, TP's therapeutic potential is limited by severe
Kuo-Feng Huang et al.
Free radical biology & medicine, 141, 220-232 (2019-06-21)
Ultraviolet (UV) irradiation causes cellular oxidative stress. Under redox imbalance, Keap1-dependent Nrf2 degradation is minimal. In this study, we examined the role of Ca2+ in Nrf2 homeostasis after UVB irradiation using human dermal fibroblasts. UVB irradiation stimulates 12-lipoxygenase and the
Siyao Li et al.
Archives of toxicology, 93(9), 2673-2687 (2019-08-29)
Increasing evidence indicates that developmental exposure to nonylphenol (NP) causes damage to the central nervous system (CNS). As the most unique and primary component of neuron, axon is an essential structure for the CNS function. Here, we investigated whether developmental
Joanna H Sliwowska et al.
Alcoholism, clinical and experimental research, 38(11), 2780-2789 (2014-11-26)
Prenatal alcohol exposure (PAE) has adverse effects on reproductive function and hypothalamic-pituitary-gonadal (HPG) activity. Kisspeptin neurons play a role in mediating feedback effects of estradiol (E2 ) and progesterone (P4 ) on the HPG axis. We hypothesized that PAE will
Mingyi Yang et al.
Scientific reports, 5, 17409-17409 (2015-12-01)
The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxidative stress; however, its molecular function is unknown. We employed RNA sequencing to examine the role of human OXR1 for genome wide transcription regulation. In total, in non-treated and
S M Wabaidur et al.
Luminescence : the journal of biological and chemical luminescence, 29(6), 684-688 (2014-10-23)
A sensitive flow-injection chemiluminescence method for the determination of acetylsalicylic acid is described. It is based on the enhanced chemiluminescent emission of the alkaline lucigenin–H2O2 system by acetylsalicylic acid. The difference in chemiluminescent intensity of alkaline lucigenin–H2O2 in the presence
Melissa H Lash et al.
Langmuir : the ACS journal of surfaces and colloids, 31(3), 898-905 (2014-07-02)
Particle-based crystals have been explored in the literature for applications in molecular electronics, photonics, sensors, and drug delivery. However, much of the research on these crystals has been focused on particles of nano- and submicrometer dimensions (so-called colloidal crystals) with
Steven J Conrad et al.
Journal of experimental & clinical cancer research : CR, 34, 19-19 (2015-04-19)
Colorectal cancers are significant causes of morbidity and mortality and existing therapies often perform poorly for individuals afflicted with advanced disease. Oncolytic virotherapy is an emerging therapeutic modality with great promise for addressing this medical need. Herein we describe the
Paula Santoyo-Ramos et al.
PloS one, 9(11), e112580-e112580 (2014-11-15)
This study examined the role played by hypoxia-inducible factors (HIFs) in malignant phenotype maintenance and canonical Wnt signaling. Under normoxia, we determined that both HIF-1α and HIF-2α are expressed in human colon cancer cells but not in their non-malignant counterparts.
Rana Barakat et al.
MicrobiologyOpen, 3(1), 1-14 (2013-12-07)
The blue-green phenazine, Pyocyanin (PYO), is a well-known virulence factor produced by Pseudomonas aeruginosa, notably during cystic fibrosis lung infections. It is toxic to both eukaryotic and bacterial cells and several mechanisms, including the induction of oxidative stress, have been
Fu-Chao Liu et al.
Shock (Augusta, Ga.), 43(5), 470-474 (2015-02-19)
Casodex (bicalutamide), an androgen receptor antagonist, is used for the treatment of prostate cancer. Recent evidences show that Akt signaling pathway exerts organ-protective effects after injury. The aim of this study was to investigate whether Akt plays any role in
Abubakr M Idris et al.
Environmental science and pollution research international, 22(21), 17012-17021 (2015-07-01)
Jizan fishers are the major fish source for more than 1.5 million populations in the southern region in Saudi Arabia. Despite the overgrowing of various man-made activities in Jizan City, no recent study on environmental monitoring was reported. In the
Maria Zoupa et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 137, 111117-111117 (2020-01-14)
A challenge in cumulative risk assessment is to model hazard of mixtures. EFSA proposed to only combine chemicals linked to a defined endpoint, in so-called cumulative assessment groups, and use the dose-addition model as a default to predict combined effects.
Noriko Nakajima et al.
Journal of pharmacological sciences, 127(3), 339-343 (2015-04-04)
Oral mucositis induced by radiotherapy for cancers of the head and neck reduce the quality of life of patients. However, effective therapeutic agents are lacking. Symptomatic treatment involves local anesthesia and analgesia. We focused on the antioxidant effects of edaravone
T Çavusoglu et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 122(6), 327-333 (2014-06-19)
One of the major concerns is a nephropathy in diabetes, which applies many different kinds of medicines. However, required level of the treatment of renal disease has not been achieved. To investigate and compare the effect of the enalapril and
Joseph A Caruso et al.
Breast cancer research : BCR, 16(6), 3417-3417 (2015-01-01)
Elafin is an endogenous serine protease inhibitor. The majority of breast cancer cell lines lack elafin expression compared to human mammary epithelial cells. In this study, we hypothesized that elafin is downregulated during breast and ovarian tumorigenesis. We examined elafin
Angela Zanatta et al.
Life sciences, 93(4), 161-168 (2013-06-29)
Cerebellar ataxia is commonly observed in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, an inherited metabolic disorder biochemically characterized by ornithine (Orn), homocitrulline (Hcit) and ammonia accumulation. Since the pathophysiology of cerebellum damage in this disorder is still unknown, we investigated the effects of
Rushi Gandhi et al.
American journal of physiology. Renal physiology, 307(2), F205-F221 (2014-05-16)
Efficient clearance of apoptotic cells (efferocytosis) prevents inflammation and permits repair following tissue injury. Kidney injury molecule-1 (KIM-1) is a receptor for phosphatidylserine, an "eat-me" signal exposed on the surface of apoptotic cells that marks them for phagocytic clearance. KIM-1
Fernando Henrique Borba et al.
Environmental technology, 34(5-8), 653-661 (2013-07-11)
In this work, an optimized photo-Fenton process was applied to remove pollutants from tannery industrial effluent (TIE) with its final toxicity level being assessed by a lettuce-seed-based bioassay test. A full 33 factorial design was applied for the optimization of
Yuji Nakamaru et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 152(1), 48-52 (2014-11-21)
Many proinflammatory cytokines are regulated by the acetylation and deacetylation of the core histone. Since dysregulation of T helper 2 cytokine production is a key in the pathogenesis of allergic diseases, we examined the role of histone deacetylase (HDAC) on
Lydia Herrmann et al.
PloS one, 10(3), e0119423-e0119423 (2015-03-24)
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons
Tian Wang et al.
Toxicology mechanisms and methods, 24(8), 560-566 (2014-08-20)
Escin, a natural mixture of triterpenoid saponin isolated from the seed of the horse chestnut, is reported to have a potent antiulcer activity against ethanol-induced gastric mucosal lesions. This study investigated the possible mechanisms underlying the gastroprotective effect of escin
Xiaojin Zhang et al.
International journal of oncology, 46(3), 1141-1148 (2014-12-30)
Breast cancer is the most common malignancy in women. The Notch signaling pathway has been shown to be associated with the development and progression of many human cancers, including breast cancer, but the precise mechanism remains unknown. Here, the influence
Mohammad Parwez Ahmad et al.
Pakistan journal of pharmaceutical sciences, 28(2), 509-513 (2015-03-03)
Lipopolysaccharide (LPS) induced oxidative stress and impairment of normal physiological function generally categorized by increased anxiety and reduced mobility. Therefore, the present study was to find out the effect Methanolic extract of Asparagus racemosus (MEAR ) in lipopolysaccharide (LPS)-induced oxidative
Cristian Turato et al.
Scientific reports, 5, 17701-17701 (2015-12-05)
SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood. Overexpression of Myc often correlates with more aggressive tumour forms, supporting its involvement
Tilman D Rachner et al.
Breast cancer research : BCR, 16(1), R20-R20 (2014-02-18)
Amino-bisphosphonates and statins inhibit the mevalonate pathway, and may exert anti-tumor effects. The Wnt inhibitor dickkopf-1 (DKK-1) promotes osteolytic bone lesions by inhibiting osteoblast functions and has been implicated as an adverse marker in multiple cancers. We assessed the effects
Walid M Ebeid et al.
Analytical and bioanalytical chemistry, 406(26), 6701-6712 (2014-09-06)
A RP-LC method was developed and validated for simultaneous determination of the active components, azilsartan medoxomil (AZL) and chlorthalidone (CLT), in their novel antihypertensive combined recipe. The chromatographic separation was achieved on an Eclipse XDB-C18 (4.6 × 150 mm, 5 μm) column using a mobile
F Q Hu et al.
Journal of biological regulators and homeostatic agents, 28(4), 649-657 (2015-01-27)
Pentraxin-3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity of malignancies, but the function and molecular underlying mechanisms of PTX3 remain unclear. In the present study, the expression of PTX3 in
Jingru Zhao et al.
British journal of pharmacology, 172(20), 5009-5023 (2015-08-04)
Recent findings suggest the importance of inflammation in the pathogenesis of cerebral ischaemia and its potential as a therapeutic target. Cinnamaldehyde is a diterpene with a wide range of anti-inflammatory effects thus may be advantageous in the treatment of cerebral
Andra C Dumitru et al.
Nanoscale, 7(47), 20267-20276 (2015-11-19)
We have measured the intermolecular forces between small interference RNA (siRNA) and polyamidoamine dendrimers at the single molecular level. A single molecule force spectroscopy approach has been developed to measure the unbinding forces and energies between a siRNA molecule and
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