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Daniel Soetkamp et al.
Basic research in cardiology, 109(5), 433-433 (2014-08-15)
S-nitrosation (SNO) of connexin 43 (Cx43)-formed channels modifies dye uptake in astrocytes and gap junctional communication in endothelial cells. Apart from forming channels at the plasma membrane of several cell types, Cx43 is also located at the inner membrane of
Katja Grabowski et al.
PloS one, 10(2), e0116807-e0116807 (2015-02-04)
Reactivation of fetal gene expression patterns has been implicated in common cardiac diseases in adult life including left ventricular (LV) hypertrophy (LVH) in arterial hypertension. Thus, increased wall stress and neurohumoral activation are discussed to induce the return to expression
Tyler M Basting et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 527-543 (2015-01-16)
In conscious mammals, hypoxia or hypercapnia stimulates breathing while theoretically exerting opposite effects on central respiratory chemoreceptors (CRCs). We tested this theory by examining how hypoxia and hypercapnia change the activity of the retrotrapezoid nucleus (RTN), a putative CRC and
Ming Li Chou et al.
PloS one, 10(4), e0122300-e0122300 (2015-04-16)
Cases of variant Creutzfeldt-Jakob disease in people who had consumed contaminated meat products from cattle with bovine spongiform encephalopathy emphasize the need for measures aimed at preventing the transmission of the pathogenic prion protein (PrPSc) from materials derived from cattle.
Rodolfo Ungerfeld et al.
Theriogenology, 84(7), 1067-1074 (2015-07-16)
The objective was to characterize the stress response and the seminal parameters obtained with electroejaculation (EE) or transrectal ultrasound-guided massage of the accessory sex glands (TUMASG) in two captive but nondomestic ruminants, the mouflons and the Iberian ibex under general
D E Rico et al.
Journal of dairy science, 97(9), 5637-5644 (2014-07-16)
A variable response to fat supplementation has been reported in dairy cows, which may be due to cow production level, environmental conditions, or diet characteristics. In the present experiment, the effect of a high palmitic acid supplement was investigated relative
Umarat Srisawat et al.
Biological & pharmaceutical bulletin, 38(5), 753-762 (2015-05-08)
Ischemia and subsequent reperfusion are known to impair renal function. We examined several agents that might prevent renal impairment or enhance the recovery of renal function after ischemia/reperfusion injury in rats. Different degrees of preventive effects were observed in rats
Meng-Chieh Hsu et al.
Reproduction (Cambridge, England), 147(6), 835-845 (2014-02-26)
Kisspeptin acts as an upstream regulator of the hypothalamus-pituitary-gonad axis, which is one of the main regulatory systems for mammalian reproduction. Kiss1 and its receptor Kiss1r (also known as G protein-coupled receptor 54 (Gpr54)) are expressed in various organs, but
Abdel-Azeem M El-Mazary et al.
Italian journal of pediatrics, 41, 83-83 (2015-10-30)
Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result devastating consequences. The principle mechanisms underlying neurological damage in HIE resulting from hypoxemia and/or ischemia is deprivation of glucose and oxygen supply which
Shih-Wey Yeh et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(45), 16035-16046 (2015-09-26)
As opposed to the reversible redox reaction ({Fe(NO)2 }(10) reduced-form DNIC [(NO)2 Fe(S(CH2 )3 S)](2-) (1)⇌{Fe(NO)2 }(9) oxidized-form [(NO)2 Fe(S(CH2 )3 S)](-) ), the chemical oxidation of the {Fe(NO)2 }(10) DNIC [(NO)2 Fe(S(CH2 )2 S)](2-) (2) generates the dinuclear {Fe(NO)2
Piotr Koprowski et al.
Biochimica et biophysica acta, 1848(8), 1678-1686 (2015-05-11)
Bacterial mechanosensitive channel of small conductance (MscS) is a protein, whose activity is modulated by membrane tension, voltage and cytoplasmic crowding. MscS is a homoheptamer and each monomer consists of three transmembrane helices (TM1-3). Hydrophobic pore of the channel is
Yasuto Kinose et al.
Oncotarget, 6(13), 11342-11356 (2015-04-04)
During the dissemination of ovarian cancer cells, the cells float in the peritoneal cavity without access to a vascular supply and so are exposed to hypoxic conditions, which may cause the ovarian cancer cells to acquire a more aggressive and
Robert A Fenton et al.
American journal of physiology. Renal physiology, 308(12), F1409-F1420 (2015-05-01)
Caffeine is one of the most widely consumed behavioral substances. We have previously shown that caffeine- and theophylline-induced inhibition of renal reabsorption causes diuresis and natriuresis, an effect that requires functional adenosine A1 receptors. In this study, we tested the
Kazuhito Goda et al.
Microscopy research and technique, 78(8), 715-722 (2015-06-23)
Bioluminescence microscopy has revealed that gene expression in individual cells can respond differently to the same stimulus. To understand this phenomenon, it is important to sequentially observe the series of events from cellular signal transduction to gene expression regulated by
Emmeline E Calkoen et al.
International journal of cardiology, 183, 249-257 (2015-02-24)
Sinus node dysfunction is frequently observed in patients with congenital heart disease (CHD). Variants in the Vascular Endothelial Growth Factor-A (VEGF) pathway are associated with CHD. In Vegf(120/120) mice, over-expressing VEGF120, a reduced sinoatrial node (SAN) volume was suggested. Aim
Huseyin Altug Cakmak et al.
Therapeutics and clinical risk management, 11, 1641-1648 (2015-11-21)
Hypertension, diabetes mellitus, and osteoporosis are important comorbidities commonly seen in postmenopausal women. The aim of the present study was to investigate the relationships between blood pressure, blood glucose, and bone mineral density (BMD) in postmenopausal Turkish women. In this
David J Civitello et al.
Ecology, 94(2), 380-388 (2013-05-23)
As natural enemies, parasites can dramatically harm host populations, and even catalyze their decline. Thus, identifying factors that promote disease spread is paramount. Environmental factors can drive epidemics by altering traits involved in disease spread. For example, nutrients (such as
Yijin Wang et al.
Gastroenterology, 146(7), 1775-1783 (2014-03-04)
Many recipients of organ transplants develop chronic hepatitis, due to infection with the hepatitis E virus (HEV). Although chronic HEV infection is generally associated with immunosuppressive therapies, little is known about how different immunosuppressants affect HEV infection. A subgenomic HEV
Synthesis and reactivity of a stable silylene.
Haaf M, et al.
Journal of the American Chemical Society, 120(49), 12714-12719 (1998)
Youngtae Jeong et al.
Molecular cancer therapeutics, 14(8), 1951-1961 (2015-05-03)
The anticancer actions of vitamin D and its hormonally active form, calcitriol, have been extensively documented in clinical and preclinical studies. However, the mechanisms underlying these actions have not been completely elucidated. Here, we examined the effect of dietary vitamin
Jeroen C G den Burger et al.
Analytical and bioanalytical chemistry, 407(2), 621-627 (2014-11-07)
We developed a method for the analysis of creatinine in dried blood spot (DBS) samples to facilitate monitoring of renal function in combination with TDM of immunosuppressive drugs for transplant patients outside the hospital. An 8-mm disc of the DBS
Mahmoud Amouzadeh Tabrizi et al.
Biosensors & bioelectronics, 69, 100-105 (2015-02-25)
Herein, an easy and cost-effective approach to the immobilization of probe was performed. The amino modified salmonella ssDNA probe sequence was covalently linked with carboxylic group on the surface of nanoporous glassy carbon electrode to prepare the DNA biosensor. The
Hironori Kamii et al.
The European journal of neuroscience, 41(9), 1126-1138 (2015-02-26)
The laterodorsal tegmental nucleus (LDT) is a brainstem nucleus implicated in reward processing and is one of the main sources of cholinergic afferents to the ventral tegmental area (VTA). Neuroplasticity in this structure may affect the excitability of VTA dopamine
Anders Jorgensen et al.
BMC psychiatry, 15, 67-67 (2015-04-17)
Schizophrenia is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, and the L-arginine:ADMA ratio are markers of endothelial dysfunction that predict mortality and adverse outcome in a range of cardiovascular
Ni Y Feng et al.
BMC genomics, 16, 408-408 (2015-05-28)
Vocalization is a prominent social behavior among vertebrates, including in the midshipman fish, an established model for elucidating the neural basis of acoustic communication. Courtship vocalizations produced by territorial males are essential for reproductive success, vary over daily and seasonal
Caroline M Lai et al.
The Journal of infectious diseases, 211(3), 383-393 (2014-08-26)
Viruses that cause systemic disease often spread through the bloodstream to infect target tissues. Although viremia is an important step in the pathogenesis of many viruses, how viremia is established is not well understood. Reovirus has been used to dissect
Tao Lin et al.
Animal reproduction science, 152, 65-76 (2014-12-10)
The effects of different denuding procedures used during the in vitro culture of porcine embryos on oocyte damage and aspects of porcine embryo development were investigated in a series of studies. Oocytes were denuded by vortexing or pipetting after 44h
Zhenyu Xiao et al.
Cancer letters, 360(2), 302-309 (2015-02-28)
Human hepatocellular carcinoma (HCC) has a high rate of tumor recurrence and metastasis, resulting in shortened survival times. The efficacy of current systemic therapies for HCC is limited. In this study, we used xenograft tumor models to investigate the use
S Hassanpour et al.
British poultry science, 56(4), 443-451 (2015-06-09)
The aim of the current study was to investigate the interaction of the nitric oxide and cannabinoidergic systems on feeding behaviour in neonatal chicken. A total of 6 experiments were designed to evaluate the interaction between cannabinoidergic and nitrergic systems
Judyta Cielecka-Piontek et al.
Pharmaceutical development and technology, 20(2), 146-152 (2013-11-14)
The kinetic and thermodynamic parameters of degradation of clavulanate potassium in the solid state were studied by using a reversed phase high performance liquid chromatography (RP-HPLC) method. The degradation of clavulanate potassium was a first-order reaction depending on the substrate
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