Yolanda Karla Cupertino da Silva et al.
Molecules (Basel, Switzerland), 19(6), 8456-8471 (2014-06-24)
Different chemotypes are described as anti-inflammatory. Among them the N-acylhydrazones (NAH) are highlighted by their privileged structure nature, being present in several anti-inflammatory drug-candidates. In this paper a series of functionalized 3-aminothiophene-2-acylhydrazone derivatives 5a-i were designed, synthesized and bioassayed. These