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Iván Bihari et al.
Clinical and vaccine immunology : CVI, 19(12), 1943-1948 (2012-10-20)
Preparedness against an A/H5N1 influenza pandemic requires well-tolerated, effective vaccines which provide both vaccine strain-specific and heterologous, cross-clade protection. This study was conducted to assess the immunogenicity and safety profile of an MF59-adjuvanted, prepandemic influenza vaccine containing A/turkey/Turkey/01/2005 (H5N1) strain
E Ojeda et al.
Organic & biomolecular chemistry, 13(4), 1068-1081 (2014-11-22)
We designed niosomes based on three lipids that differed only in the polar-head group to analyze their influence on the transfection efficiency. These lipids were characterized by small-angle X-ray scattering before being incorporated into the niosomes which were characterized in
Qiyan Xiong et al.
Vaccine, 32(27), 3445-3451 (2014-04-16)
Mycoplasma hyopneumoniae (M. hyopneumoniae) vaccine strain 168 is an intrapulmonically injected attenuated live vaccine that is available in the Chinese market. The aim of this study was to develop suitable adjuvants for this live vaccine to provide effective protection after
Yan Sun et al.
Molecular biology reports, 40(2), 2035-2044 (2012-12-15)
Isoprenoid is the precursor for the biosynthesis of saponins, abscisic acid, gibberellins, chlorophylls and many other products in plants. Saponins are an important group of bioactive plant natural products. The alfalfa (Medicago sativa L.) saponins are glycosides of different triterpene
F Rubinstein et al.
BMJ (Clinical research ed.), 346, f393-f393 (2013-02-06)
To assess the risk of adverse perinatal events of vaccination of pregnant women with an MF59 adjuvanted vaccine. Cross sectional multicentre study. 49 public hospitals in major cities in Argentina, from September 2010 to May 2011. 30,448 mothers (7293 vaccinated)
Yun Xia et al.
Cell, 175(4), 1059-1073 (2018-10-03)
Motivated by the clinical observation that interruption of the mevalonate pathway stimulates immune responses, we hypothesized that this pathway may function as a druggable target for vaccine adjuvant discovery. We found that lipophilic statin drugs and rationally designed bisphosphonates that
L Harivardhan Reddy et al.
Advanced drug delivery reviews, 61(15), 1412-1426 (2009-10-07)
Squalene is a natural lipid belonging to the terpenoid family and a precursor of cholesterol biosynthesis. It is synthesized in humans and also in a wide array of organisms and substances, from sharks to olives and even bran, among others.
Hideaki Kabuto et al.
Journal of oleo science, 62(1), 21-28 (2013-01-30)
Active oxygen has been implicated in the pathogenesis of Parkinson's disease (PD); therefore, antioxidants have attracted attention as a potential way to prevent this disease. Squalene, a natural triterpene and an intermediate in the biosynthesis of cholesterol, is known to
Marc Montana et al.
Therapie, 65(6), 533-541 (2010-12-24)
Few studies show the reluctance of the people to get vaccinated against A (H1N1) influenza for fear of side effects of squalene (MF59, AS03, AF03) and thimerosal. The aim of this paper is to assess the safety in using these
Se-Kwon Kim et al.
Advances in food and nutrition research, 65, 223-233 (2012-03-01)
Squalene is a polyunsaturated hydrocarbon with a formula of C₃₀H₅₀. Squalene can be found in certain fish oils, especially shark liver oil, in high amounts and some vegetable oils in relatively smaller amounts. Human sebum also contains 13% squalene as
Richard E Ostlund et al.
Nutrition reviews, 60(11), 349-359 (2002-12-05)
The effect of dietary fats on serum cholesterol is widely assumed to be due solely to the fatty acids and cholesterol they contain. Phytosterols, sterol oxidation products, and sterol precursors such as squalene, however, are often present in dietary fats.
Richard Puleston et al.
PloS one, 8(1), e47448-e47448 (2013-02-02)
Illness and death from influenza increase during pregnancy. In the United Kingdom pregnant women were targeted in a national programme for vaccination during the H1N1 2009-10 pandemic. In this study, pregnant women were recruited in labour from November 9, 2009
Amporn Suphatrakul et al.
Vaccine, 33(42), 5613-5622 (2015-09-19)
Recent phase IIb/III trials of a tetravalent live attenuated vaccine candidate revealed a need for improvement in the stimulation of protective immunity against diseases caused by dengue type 2 virus (DENV-2). Our attempts to develop particulate antigens for possibly supplementing
Jamie F S Mann et al.
Journal of controlled release : official journal of the Controlled Release Society, 170(3), 452-459 (2013-06-19)
Vaccination through mucosal surfaces has been shown to elicit antiviral immune responses against a number of mucosal pathogens. Here we demonstrate that both mucosal and systemic immune responses can be elicited against a model HIV-1 CN54gp140 antigen when cation-complexed plasmid
Yuan-Ting Liu et al.
Organic letters, 14(20), 5222-5225 (2012-10-10)
A Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase mutant, ERG7(T384Y/Q450H/V454I), produced parkeol but not lanosterol as the sole end product. Parkeol undergoes downstream metabolism to generate compounds 9 and 10. In vitro incubation of parkeol produced a product profile similar to that of
Giuseppe Del Giudice et al.
Current topics in microbiology and immunology, 386, 151-180 (2014-07-21)
Inactivated influenza vaccines are produced every year to fight against the seasonal epidemics of influenza. Despite the nonoptimal coverage, even in subjects at risk like the elderly, pregnant women, etc., these vaccines significantly reduce the burden of mortality and morbidity
Maria Vono et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(52), 21095-21100 (2013-12-11)
Vaccines are the most effective agents to control infections. In addition to the pathogen antigens, vaccines contain adjuvants that are used to enhance protective immune responses. However, the molecular mechanism of action of most adjuvants is ill-known, and a better
Minh T Ta et al.
The FEBS journal, 279(22), 4231-4244 (2012-09-28)
The isoprenoid squalene is an important precursor for the biosynthesis of sterols. The cellular storage of squalene and its impact on membrane properties have been the subject of recent investigations. In a screen for abnormal lipid droplet morphology and distribution
Akihiro Michihara et al.
Biological & pharmaceutical bulletin, 38(12), 1879-1890 (2015-12-04)
A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously hypertensive rats stroke-prone (SHRSP) have lower serum cholesterol levels than normotensive Wistar-Kyoto rats (WKY). To elucidate the mechanisms responsible
Jose A Plaza et al.
The American Journal of dermatopathology, 37(11), 809-821 (2015-10-21)
Sebaceous carcinoma (SC) is a relatively uncommon malignant epithelial neoplasm with a predilection for the periocular region. The diagnosis of SC can be difficult to make at initial presentation, as it can clinically and histopathologically resemble other common benign and
C Scialabba et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 695-705 (2014-10-05)
This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed
Tomonori Takami et al.
PloS one, 7(11), e49004-e49004 (2012-11-13)
Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation. Thus, it is difficult to study the effects of the inhibition of various enzymes on
Shirya Rashid et al.
Circulation, 130(5), 431-441 (2014-07-30)
Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also
David R Fooshee et al.
Environmental science & technology, 49(22), 13304-13313 (2015-10-23)
Squalene is a major component of skin and plant surface lipids and is known to be present at high concentrations in indoor dust. Its high reactivity toward ozone makes it an important ozone sink and a natural protectant against atmospheric
T R Tansey et al.
Biochimica et biophysica acta, 1529(1-3), 49-62 (2000-12-09)
Mammalian squalene synthase (SQS) catalyzes the first reaction of the branch of the isoprenoid metabolic pathway committed specifically to sterol biosynthesis. SQS produces squalene in an unusual two-step reaction in which two molecules of farnesyl diphosphate are condensed head-to-head. Recent
Ruchi R Shah et al.
Journal of pharmaceutical sciences, 104(4), 1352-1361 (2015-01-21)
Microfluidization is an established technique for preparing emulsion adjuvant formulations for use in vaccines. Although this technique reproducibly yields high-quality stable emulsions, it is complex, expensive, and requires proprietary equipment. For this study, we developed a novel and simple low
[Research progress on the squalene synthase].
Mingwen Zhao et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 43(5), 676-680 (2005-11-12)
Andrei Maksimenko et al.
International journal of pharmaceutics, 482(1-2), 38-46 (2014-12-03)
Gemcitabine is currently the most effective agent against advanced pancreatic cancer. However, the major therapeutic hurdles using gemcitabine include rapid inactivation by blood deaminases and fast development of cell chemoresistance, induced by down-regulation of deoxycytidine kinase or nucleoside transporters. To
Michael R Rasch et al.
Langmuir : the ACS journal of surfaces and colloids, 28(43), 15160-15167 (2012-10-05)
Assemblies of saturated 1,2-diacylphosphatidylcholine lipid and hydrophobic dodecanethiol-capped 1.8 nm diameter gold nanocrystals were studied as a function of lipid chain length and the addition of the naturally occurring oil, squalene. The gold nanocrystals formed various lipid-stabilized agglomerates, sometimes fusing
Queries about vaccines containing squalene.
Frances Beck et al.
Immunology and cell biology, 88(5), 497-499 (2010-02-17)
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