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K Krishnanunni et al.
Journal of food science and technology, 52(5), 2572-2584 (2015-04-22)
The objective of this study is to analyze the chemical composition and volatiles present in two medicinal rice varieties of "karungkuravai" and "mappilai samba" and to investigate their total phenolic content and bio activity. Chemical composition of the rice varieties
Shuxin Han et al.
Nature communications, 6, 7231-7231 (2015-06-05)
Circadian control of nutrient availability is critical to efficiently meet the energetic demands of an organism. Production of bile acids (BAs), which facilitate digestion and absorption of nutrients, is a major regulator of this process. Here we identify a KLF15-Fgf15
Subburayan Karthikeyan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 274-282 (2015-03-18)
Previously, we reported that the prepared resveratrol (RSV) loaded gelatin nanoparticles (GNPs) possessed enhanced anticancer effect than free RSV in non-small cell lung carcinoma cells and Swiss albino mice. The present study aims to explore the relevant mechanism of cell
Mahesh Mohan et al.
Journal of immunology (Baltimore, Md. : 1950), 194(1), 291-306 (2014-12-03)
Persistent gastrointestinal inflammation, a hallmark of progressive HIV/SIV infection, causes disruption of the gastrointestinal epithelial barrier, microbial translocation, and generalized immune activation/inflammation driving AIDS progression. Apart from protein regulators, recent studies strongly suggest critical roles for microRNAs (miRNAs) in regulating
Yi-Fei Chen et al.
International journal of molecular medicine, 34(6), 1591-1598 (2014-10-17)
The difficulties faced in the effective treatment of ovarian cancer are multifactorial, but are mainly associated with relapse and drug resistance. Cancer stem-like cells have been reported to be an important contributor to these hindering factors. In this study, we
Mauricio Montaño-Rendón et al.
Zootaxa, 4034(3), 495-514 (2015-12-02)
The Rufous-backed Robin (Turdus rufopalliatus) is endemic to deciduous and semideciduous tropical forests of western Mexico. Of the currently recognized subspecies, T. r. graysoni, from the Tres Marías Islands and nearby coastal Nayarit, has been considered a separate species; however
B I Tamba et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 46-55 (2015-02-15)
The current progress in pharmaceutical nanotechnology field has been exploited in the design of functionalized radiolabelled nanoparticles that are able to deliver radionuclides in a selective manner to improve the outcome of diagnosis and treatment. Silica nanoparticles (SNPs) have been
Christoph Roderburg et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1172-1184 (2014-07-22)
Serum concentrations of miR-122 were proposed as a marker for various inflammatory diseases, but the mechanisms driving alterations in miR-122 serum levels are unknown. We analysed miR-122 serum levels and hepatic miR-122 expression in mice after hepatic ischaemia and reperfusion
Xin Zhao et al.
Molecular medicine reports, 12(2), 3191-3199 (2015-05-09)
In the present study, the therapeutic effects of Lactobacillus casei Qian (LC-Qian), the key microorganism in Tibetan yak yoghurt, on activated carbon-induced constipation were determined in vivo. ICR mice were treated with LC-Qian for nine days by oral administration. The
Qian Zhong et al.
Gene, 556(1), 74-79 (2014-12-03)
Emerging evidence has indicated that alcohol consumption is an established risk factor for breast cancer. Deregulation of RNA polymerase III (Pol III) transcription enhances cellular Pol III gene production, leading to an increase in translational capacity to promote cell transformation
Naoki Yamamoto et al.
Biochemical and biophysical research communications, 457(4), 547-553 (2015-01-21)
Recent studies have suggested that a positive correlation exists between surgical interventions performed under general anesthesia and the risk of developing Alzheimer's disease (AD) in the late postoperative period. It has been reported that amyloid β-protein (Αβ) fibrillogenesis, which is
Chiyo Kitayama et al.
The Journal of reproduction and development, 61(5), 415-421 (2015-06-23)
The structure and functions of placentas were examined in 3 species of rorqual whales, common minke (Balaenoptera acutorostrata), Bryde's (B. brydei) and sei (B. borealis) whales, with the aim of confirming the structural characteristics of the chorion, including the presence
José Ballester-Beltrán et al.
Biofabrication, 6(3), 035009-035009 (2014-05-29)
Currently, cell culture systems that include nanoscale topography are widely used in order to provide cells additional cues closer to the in vivo environment, seeking to mimic the natural extracellular matrix. Electrospinning is one of the most common techniques to
Bernhard J Jank et al.
Biomaterials, 61, 246-256 (2015-05-26)
The loss of an extremity is a disastrous injury with tremendous impact on a patient's life. Current mechanical prostheses are technically highly sophisticated, but only partially replace physiologic function and aesthetic appearance. As a biologic alternative, approximately 70 patients have
Wan Chen et al.
The Journal of steroid biochemistry and molecular biology, 152, 16-24 (2015-04-25)
Glucocorticoid-induced tendon rupture is very common in clinical practice, and the overall outcome of surgical suture repair is rather poor. The mechanism remains unclear, and effective treatments are still lacking. In the present study, we investigated the effect of dexamethasone
Janneke Hilderink et al.
Journal of cellular and molecular medicine, 19(8), 1836-1846 (2015-03-18)
Clinical islet transplantation is a promising treatment for patients with type 1 diabetes. However, pancreatic islets vary in size and shape affecting their survival and function after transplantation because of mass transport limitations. To reduce diffusion restrictions and improve islet
Georg Goliasch et al.
PloS one, 10(7), e0134479-e0134479 (2015-08-01)
Heart failure with preserved ejection fraction (HFpEF) is recognized as a major cause of cardiovascular morbidity and mortality. Thus, a profound understanding of the pathophysiologic changes in HFpEF is needed to identify risk factors and potential treatment targets in this
Clara Pérez-Mañá et al.
Pharmacological research, 95-96, 27-33 (2015-03-25)
Previous studies in animals have shown an increase of hydroxytyrosol (OHTyr), a potent phenolic antioxidant and a minor metabolite of dopamine (also called 3,4-dihydroxyphenylethanol or DOPET), after ethanol intake. The interaction between ethanol and dopamine metabolism is the probable mechanism
Kavous Firouznia et al.
Cardiovascular and interventional radiology, 38(4), 977-984 (2015-05-07)
Renal nerves are a recent target in the treatment of hypertension. Renal sympathetic denervation (RSD) is currently performed using catheter-based radiofrequency ablation (RFA) and because this method has limitations, percutaneous magnetic resonance (MR)-guided periarterial ethanol injection is a suggested alternative.
Andrei Chekkoury et al.
Biomedical optics express, 6(9), 3134-3148 (2015-09-30)
Optical mesoscopy extends the capabilities of biological visualization beyond the limited penetration depth achieved by microscopy. However, imaging of opaque organisms or tissues larger than a few hundred micrometers requires invasive tissue sectioning or chemical treatment of the specimen for
Deanna Siow et al.
Journal of lipid research, 56(4), 898-908 (2015-02-19)
The ORM1 (Saccharomyces cerevisiae)-like proteins (ORMDLs) and their yeast orthologs, the Orms, are negative homeostatic regulators of the initiating enzyme in sphingolipid biosynthesis, serine palmitoyltransferase (SPT). Genome-wide association studies have established a strong correlation between elevated expression of the endoplasmic
Zeynep Aytac et al.
Colloids and surfaces. B, Biointerfaces, 128, 331-338 (2015-03-15)
Herein, hydroxypropyl-beta-cyclodextrin (HPβCD) inclusion complex (IC) of a hydrophobic drug, sulfisoxazole (SFS) was incorporated in hydroxypropyl cellulose (HPC) nanofibers (HPC/SFS/HPβCD-IC-NF) via electrospinning. SFS/HPβCD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex
Maris Vilums et al.
ChemMedChem, 10(7), 1249-1258 (2015-06-03)
Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy. We previously described a
Sumihiro Koyama et al.
Marine biotechnology (New York, N.Y.), 17(5), 678-692 (2015-08-06)
The purpose of this study was to develop a novel electrical retrieval method (ER method) for living sponge-associated microorganisms from marine sponges frozen at -80 °C. A -0.3-V vs. Ag/AgCl constant potential applied for 2 h at 9 °C induced
Liyun Ma et al.
Journal of chromatography. A, 1376, 64-73 (2014-12-22)
Cucurbit[7]uril (CB7), one host macromolecule, possesses a hydrophobic inner cavity and two identical hydrophilic carbonyl fringe portals, thus interacting with a variety of guest molecules through hydrophobic, hydrogen bonding and ion-dipole interactions. These characteristics make CB7 a good candidate as
Michelle M Lorah et al.
Biodegradation, 26(5), 341-357 (2015-07-15)
Anaerobic, fixed film, bioreactors bioaugmented with a dechlorinating microbial consortium were evaluated as a potential technology for cost effective, sustainable, and reliable treatment of mixed chlorinated ethanes and ethenes in groundwater from a large groundwater recovery system. Bench- and pilot-scale
Eirini G Velliou et al.
Bioprocess and biosystems engineering, 38(8), 1589-1600 (2015-04-26)
A great challenge when conducting ex vivo studies of leukaemia is the construction of an appropriate experimental platform that would recapitulate the bone marrow (BM) environment. Such a 3D scaffold system has been previously developed in our group [1]. Additionally
Lifeng Liu et al.
Plant physiology, 168(2), 549-560 (2015-04-15)
The predominant structure of the hemicellulose xyloglucan (XyG) found in the cell walls of dicots is a fucogalactoXyG with an XXXG core motif, whereas in the Poaceae (grasses and cereals), the structure of XyG is less xylosylated (XXGGn core motif)
Ke Liu et al.
Bioresource technology, 196, 716-720 (2015-08-09)
A two stage hydrolysis of corn stover was designed to solve the difficulties between sufficient mixing at high solids content and high power input encountered in large scale bioreactors. The process starts with the quick liquefaction to convert solid cellulose
Monalisa Pal et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(8), 1627-1634 (2015-04-14)
To develop CoFe(2)O(4) as magneto-fluorescent nanoparticles (NPs) for biomedical applications, it would be advantageous to identify any intrinsic fluorescence of this important magnetic material by simply adjusting the surface chemistry of the NPs themselves. Herein, we demonstrate that intrinsic multicolor
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